4hac

Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazeiCrystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei

Structural highlights 4hac is a 2 chain structure with sequence from Methanosarcina mazei Go1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.92Å Ligands: , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q8PW39_METMA Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.[HAMAP-Rule:MF_00217] Publication Abstract from PubMed Mevalonate kinase (MVK), which plays an important role in catalysing the biosynthesis of isoprenoid compounds derived from the mevalonate pathway, transforms mevalonate to 5-phosphomevalonate using ATP as a cofactor. Mevalonate kinase from Methanosarcina mazei (MmMVK) was expressed in Escherichia coli, purified and crystallized for structural analysis. Diffraction-quality crystals of MmMVK were obtained by the vapour-diffusion method using 0.32 M MgCl(2), 0.08 M bis-tris pH 5.5, 16%(w/v) PEG 3350. The crystals belonged to space group P2(1)2(1)2, with unit-cell parameters a = 97.11, b = 135.92, c = 46.03 A. Diffraction data were collected to 2.08 A resolution. Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei.,Zhuang N, Seo KH, Chen C, Zhou J, Kim SW, Lee KH Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1560-3., doi: 10.1107/S1744309112047070. Epub 2012 Nov 28. PMID:23192048 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Mevalonate kinase

spinqualitylabelsall models 4hac, resolution 1.92Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image