4x30

Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolutionCrystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution

Structural highlights

4x30 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[THBG_HUMAN] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.

Function

[THBG_HUMAN] Major thyroid hormone transport protein in serum.

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