Thiol:disulfide interchange protein

Function Thiol:disulfide interchange protein is a prokaryotic disulfide bond isomerase. DsbA see Protein disulfide oxidoreductase DsbC acts as a proofreader and breaks the incorrectly formed disulfide bonds. DsbC is activated by the N terminal domain of DsbD. DsbD transfers electrons from the cytoplasmic thioredoxin to the periplasm thus maintaining the active site of DsbC, DsbE and DsbG in a reduced state. DsbE catalyzes the reductive step in the assembly of periplasmic c-type cytochrome. DsbG provides reducing equivalents to rescue oxidatively-damaged secreted proteins. Structural highlights DsbC active site contains a which modulates the disulfide isomerization and protein folding in the bacterial periplasmic space. 3D Structures of thiol:disulfide interchange protein Thiol:disulfide interchange protein 3D structures

spinqualitylabelsall models E. coli DsbC complex with MES (PDB code 1eej) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of thiol:disulfide interchange protein3D Structures of thiol:disulfide interchange protein

Updated on 20-February-2020

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• Thiol:disulfide interchange protein (DsbA) see Protein disulfide oxidoreductase

• Thiol:disulfide interchange protein (DsbB)

• • [[3e9j], 2zup] – EcDsbB (mutant) + DsbA (mutant) - Escherichal coli
    
  • 2leg] – EcDsbB (mutant) + DsbA (mutant) - NMR
    
  • 2hi7] – EcDsbB (mutant) + DsbA (mutant) + ubiquinone
    
  • 2zuq – EcDsbB (mutant) + antibody
    

• Thiol:disulfide interchange protein (DsbC)

• • 1eej, 1tjd – EcDsbC
    
  • 1g0t, 1jzo – EcDsbC (mutant)
    
  • 2iyj – EcDsbC N terminal
    
  • 1jzd – EcDsbC (mutant) + DsbD N terminal
    
  • 1t3b – DsbC – Haemophilus influenzae
    
  • 4fyb, 4fyc – HpDsbC – Helicobacter pylori
    
  • 4i5q – StDsbC – Salmonella typhimurium
    
  • 4ilf – StDsbC (mutant)
    
  • 4npb – DsbC – Yersinia pestis
    

• Thiol:disulfide interchange protein (DsbD)

• • 1l6p, 1jpe, 3pfu, 5nhi – EcDsbD N terminal
    
  • 1uc7, 2fwe, 2fwf 2fwg, 2fwh – EcDsbD C terminal
    
  • 4ip1, 4ip6 – EcDsbD C terminal (mutant)
    
  • 1vrs – EcDsbD N terminal (mutant) + C terminal (mutant)
    
  • 1z5y – EcDsbD N terminal (mutant) + EcDsbE soluble domain (mutant)
    
  • 2k0r, 6dnv, 6dps – NmDsbD N terminal – Neisseria meningitis
    
  • 6dnl, 6dnu – NmDsbD C terminal
    
  • 2k9f – NmDsbD N terminal + thoredoxin
    

• Thiol:disulfide interchange protein (DsbE)

• • 2b1k, 3k8n – EcDsbE
    
  • 2b1l, 2g0f – EcDsbE (mutant)
    
  • 3kh7, 3kh9 – DsbE soluble domain – Pseudomonas aeruginosa
    

• Thiol:disulfide interchange protein (DsbF)

• • 3ios – DsbF – Mycobacterium tuberculosis
    

• Thiol:disulfide interchange protein (DsbG)

• • 1v57, 1v58 – EcDsbG
    
  • 2h0g, 2h0h, 2h0i, 5g1k, 5g1l – EcDsbG (mutant)
    
  • 2iy2 – EcDsbG N terminal
    
  • 4ihu – MtDsbG
    
  • 3tdg – HpDsbG
    

• Thiol:disulfide interchange protein (DsbP)

• • 4ml1, 4ml6, 4mly – DsbP – Klebsiella pneumoniae
    

• Thiol:disulfide interchange protein (CycY)

• • 1kng – CycY – Bradyrhizobium japonicum
    

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