6adq
Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatisRespiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis
Structural highlights
Function[A0QQQ1_MYCS2] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000393] [A0R056_MYCS2] Part of cytochrome c oxidase, its function is unknown.[PIRNR:PIRNR017385] Publication Abstract from PubMedWe report a 3.5-A resolution cryo-EM structure of a respiratory supercomplex isolated from Mycobacterium smegmatis. It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate such that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV via a bridging cytochrome subunit. We observe a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for development of treatments for human tuberculosis. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.,Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F, Wang Q, Rao Z Science. 2018 Oct 25. pii: science.aat8923. doi: 10.1126/science.aat8923. PMID:30361386[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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