Hormone

In the field of modern endocrinology, a hormone is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process.

Guide to Proteopedia Pages Concerning Hormones and their ReceptorsGuide to Proteopedia Pages Concerning Hormones and their Receptors

{"openlevels":0}

Articles in Proteopedia concerning Hormone include:

• Human Follicle-Stimulating Hormone Complexed with its Receptor
• Estrogen-related receptor
• Androgen Receptor
• Leucine-rich repeat proteins
• Human growth hormone
• Vascular Endothelial Growth Factor
• Vascular Endothelial Growth Factor Receptor
• Receiver domain of sensor histidine kinase CKI1
• Beta-2 Adrenergic Receptor

To view automatically seeded indices concerning Hormone, see:

• Hormone
• Hormone Receptor
• Steroid receptor
• Steroid hormone receptor

Additional 3D Structures of Hormones and Hormone Receptors and Related MoleculesAdditional 3D Structures of Hormones and Hormone Receptors and Related Molecules

AdrenalineAdrenaline

Beta-2 Adrenergic Receptor
The human β2 adrenergic receptor bound to a hormone analog and G-protein (3sn6) is featured in an image on the right, and additional structures are on the Adrenergic receptor page.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image An activated G protein-coupled receptor (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) (3sn6), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green.

AngiotensinogenAngiotensinogen

2wxw, 2wxx, 2wxy, 2wxz, 2wy0, 2wy1, 2x0b - Angiotensinogen – human, rat, mouse

Chorionic GonadotropinChorionic Gonadotropin

1hrp - Chorionic Gonadotropin – human
1hcn - Chorionic Gonadotropin – human
1hd4 - Alpha-subunit of Chorionic Gonadotropin – human

Estrogen-related ReceptorEstrogen-related Receptor

Estrogen-related receptor

Androgen ReceptorAndrogen Receptor

Nuclear Androgen Receptor

Farnesoid X ReceptorFarnesoid X Receptor

3olf, 3omk, 3omm, 3oof, 3ook, 3okh, 3oki - Farnesoid X Receptor – human

Follicle-Stimulating HormoneFollicle-Stimulating Hormone

Follicle-stimulating hormone

PACAP/glucagon family of peptide hormonesPACAP/glucagon family of peptide hormones

3n94 - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure 2jod and vice versa
2jod - Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular

GlucocorticoidGlucocorticoid

Glucocorticoid receptor

Glucose-dependent Insulinotropic PolypeptideGlucose-dependent Insulinotropic Polypeptide

Glucose-dependent Insulinotropic Polypeptide Receptor

Growth HormoneGrowth Hormone

Human growth hormone is featured here.

InsulinInsulin

Insulin

Progesterone receptorProgesterone receptor

3hq5, 3g8o - hProgR steroid-binding domain – human
1a28 - hProgR steroid-binding domain + progesterone
4oar, 2ovm, 2ovh - hProgR steroid-binding domain + SMRT peptide
4apu, 4a2j, 1zuc - hProgR steroid-binding domain + agonist
3kba - hProgR steroid-binding domain + partial agonist
3zrb, 3zra, 3zr7 - hProgR steroid-binding domain + modulator
3d90 - hProgR steroid-binding domain + levonorgestrel
2w8y - hProgR steroid-binding domain + RU486
1sr7 - hProgR steroid-binding domain + mometasone furoate
1sqn - hProgR steroid-binding domain + northindrone
1e3k - hProgR steroid-binding domain + metribolone
2c7a - hProgR DNA-binding domain + DNA

Thyroid-Stimulating hormoneThyroid-Stimulating hormone

3g04 - TSH receptor in complex with a thyroid-stimulating autoantibody – human
2xwt - TSH receptor in complex with a thyroid-inactivating autoantibody – human

Thyroid hormoneThyroid hormone

2nll - DNA-Binding domain in complex with an inverted repeat class of thyroid response element– rat
1xzx

ThyroxineThyroxine

2xn3, 2xn5, 2xn6, 2xn7 - Thyroxine-binding Globulin – human

domain of the human splice variant hPAC1-RS determined by NMR - human

ADD 3dzu

See AlsoSee Also

• Cancer
• Membrane proteins
• G protein-coupled receptors
• Nobel Prizes for 3D Molecular Structure
• Highest impact structures of all time

External ResourcesExternal Resources

• Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors
• GRIS: Glycoprotein-hormone Receptors Information System
• The GPCR-SSFE Database: A Homology Model Resource for G-Protein Coupled Receptors
• The feature on Growth Hormone by Shuchismita Dutta and David S. Goodsell for the April 2004 RCSB PDB Molecule of the Month.
• NeuroPedia, a neuropeptide database and spectral library