1hrp

CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPINCRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN

Structural highlights 1hrp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CGB3_HUMAN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones. Crystal structure of human chorionic gonadotropin.,Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW Nature. 1994 Jun 9;369(6480):455-61. PMID:8202136 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Hormone Human Follicle-Stimulating Hormone Complexed with its Receptor

spinqualitylabelsall models 1hrp, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image