Cyclin-dependent kinase regulatory subunit

Function Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal differentiation. Structural highlights CKS exists as hexamer of homodimers and can bind six kinase molecules. 3D Structures of cyclin-dependent kinase regulatory subunit Cyclin-dependent kinase regulatory subunit 3D structures

spinqualitylabelsall models Human CKS-1 complex with phosphate (PDB code 1dks) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of cyclin-dependent kinase regulatory subunit3D Structures of cyclin-dependent kinase regulatory subunit

Updated on 21-May-2019

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• CKS 1
  • 1dks, 1dkt – hCKS 1 - human
    
  • 4lpa, 1qb3 – yCKS 1 - yeast
    
  • 3qy2 – yCKS 1 (mutant)
    
  • 1puc, 1sce – fyCKS 1 – fission yeast
    
  • 1cks – hCKS 2
    
• CKS 1 complexes
  • 4yc6 – hCKS 1 + CDK1
    
  • 1buh – hCKS 1 + CDK2
    
  • 1h4l, 1ung – hCKS 1 + CDK5
    
  • 1unh, 1unl – hCKS 1 + CDK5 + inhibitor
    
  • 3o0g – hCKS 1 + CDK5 + ATP analog
    
  • 2ass – hCKS 1 + Skp1 + Skp2
    
  • 2ast – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide
    
• CKS 2
  • 1cks – hCKS 2
    
  • 4y72, 4yc3, 5hq0, 5lqf – hCKS 2 + CDK1 + cyclin B1
    
  • 6gu2 – hCKS 2 + CDK1 + cyclin B + flavopiridol
    
  • 6gu7 – hCKS 2 + CDK1 + inhibitor
    
  • 6gu6 – hCKS 2 + CDK1 + dinaciclib
    
  • 6gu3, 6gu4 – hCKS 2 + CDK1 + cyclin B + inhibitor