Cyclin-dependent kinase regulatory subunit

Function

Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.

CKS1 is essential for CDK5 functioning in neuronal differentiation.^[1]
CKS2 is implicated as an oncogene in various malignancies.^[2]

Structural highlights

CKS exists as hexamer of homodimers and can bind six kinase molecules.

3D Structures of cyclin-dependent kinase regulatory subunit

Cyclin-dependent kinase regulatory subunit 3D structures

ReferencesReferences

↑ Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379
↑ Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019 Oct 22;2019:8964015. PMID:31781310 doi:10.1155/2019/8964015

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Michal Harel, Alexander Berchansky

[1] Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379

[2] Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019 Oct 22;2019:8964015. PMID:31781310 doi:10.1155/2019/8964015

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