BRCA

Function BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see: RING Finger Domain of BRCA1 and BARD1 Heterodimer. Mutations in BRCA1/BARD1 RING-domain heterodimer. Mutations in Brca1 BRCT Domains. Disease Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers. Structural highlights The . These domains contain most of the mutations seen in BRCA1. .

spinqualitylabelsall models Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code 3coj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of BRCA3D structures of BRCA

Updated on 03-April-2018

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• BRCA1
  • 4ofb, 4y18, 4y2g, 4u4a, 4jlu, 4ifi, 4igk, 3k0h, 3k0k, 3coj, 1y98, 1t15, 1t29, 1t2v - hBRCA1 BRCT1 domain + peptide inhibitor - human
    
  • 3pxa, 3pxb, 3pxc, 3pxd, 3pxe, 3k15, 3k16 - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor
    
  • 1jnx - hBRCA1 BRCT domain
    
  • 2ing, 1t2u, 1n5o - hBRCA1 BRCT1 domain (mutant)
    
  • 1oqa - hBRCA1 BRCT-C domain - NMR
    
  • 1l0b - BRCA1 BRCT domain - rat
    
  • 2n9e - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR
    
  • 4mkf, 4mkg - hBRCA1 SUMO-interacting motif - NMR
    
  • 1jm7 - hBRCA1 Ring domain + BARD1 ring domian - NMR
    
• BRCA2
  • 1iyj, 1miu – hBRCA2 residues 2335-3151 + DSS1
    
  • 1mje – hBRCA2 residues 2335-3151 + DSS1 + ssDNA
    
  • 1n0w – hBRCA2 BRC repeat 4 + RAD51 + linker