Syntrophin

Function Syntrophins (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling . Disease Mutations in Syn which interacts with sodium channel cause the inherited disorder long-QT syndrome resulting in sudden cardiac death. Structural highlights Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. Syn binds the neuronal NOS β-finger via its binding groove.

spinqualitylabelsall models Mouse syntrophin PDZ domain (grey) complex with neuronal NOS (green) (PDB code 1qav) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of syntrophin3D Structures of syntrophin

Updated on 25-December-2017

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• α-1-syntrophin
  • 1z86 – mSyn PDZ domain – mouse - NMR
    
  • 2adz – mSyn PH domain - NMR
    
  • 1z87 – mSyn PH+PDZ domains - NMR
    
  • 1qav – mSyn PDZ domain + BNOS
    
  • 4hop – mSyn PDZ domain (mutant) + BNOS
    
  • 2pdz – mSyn PDZ domain + voltage-gated sodium channel peptide - NMR
    
• β-2-syntrophin
  • 2vrf – Syn PDZ domain – human