Syntrophin

Function Syntrophins (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling . alpha-1-syntrophin is a cytoskeletal protein interacting with cardiac sodium channel. beta-1-syntrophin is a scaffold protein that provides a platform for the formation of signal transduction complexes. Disease Mutations in Syn which interacts with sodium channel cause the inherited disorder long-QT syndrome resulting in sudden cardiac death. Structural highlights Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. β-finger via its binding groove. 3D Structures of syntrophin Updated on 04-May-2025 {{#tree:id=OrganizedByTopic|openlevels=0| alpha-1-syntrophin 1z86 – mSyn PDZ domain – mouse - NMR 2adz – mSyn PH domain - NMR 1z87 – mSyn PH+PDZ domains - NMR 1qav – mSyn PDZ domain + BNOS 4hop – mSyn PDZ domain (mutant) + BNOS 2pdz – mSyn PDZ domain + voltage-gated sodium channel peptide - NMR beta-1-syntrophin 7pc4 – hSyn PDZ domain 107-196 + TAX-1 peptide - human 7p70 – hSyn PDZ domain + HPV35-E6 peptide beta-2-syntrophin 2vrf – hSyn PDZ domain gamma-1-syntrophin 7qqn – hSyn PDZ domain 54-143 + TRPV3 peptide 7pc7 – hSyn PDZ domain + PTEN peptide 7pc8 – hSyn PDZ domain + RSK1 peptide gamma-2-syntrophin 7qql – hSyn PDZ domain 70-159 + RSK1 peptide }}

spinqualitylabelsall models Mouse syntrophin PDZ domain (deepskyblue) complex with neuronal NOS (green) (PDB code 1qav) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image