3e9e

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Structure of full-length H11A mutant form of TIGAR from Danio rerioStructure of full-length H11A mutant form of TIGAR from Danio rerio

Structural highlights

3e9e is a 2 chain structure with sequence from Brachidanio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:zgc:56074 (Brachidanio rerio)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TIGRB_DANRE] Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3e9e, resolution 2.10Å

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OCA
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