Proteopedia

Receptor for activated protein kinase C 1

Revision as of 16:51, 23 October 2017 by Michal Harel (talk | contribs)

Function

Receptor for activated protein kinase C 1 (RACK1) is a scaffold protein which is able to interact simultaneously with several signaling molecules[1]. It binds to protein kinases and to membrane-bound receptors[2]. RACK1 is also part of the eukaryotic ribosome and it localizes to the small 40S subunit. RACK1 recruits activated protein kinase to the ribosome and allows translation to be linked to cellular stimuli[3].

Relevance

RACK1 is up-regulated in angiogenesis and human carcinomas[4]. The association of RACK1 with burial disease virus protein VP5 inhibits apoptosis and enhances viral replication[5].


Human receptor for activated protein kinase C 1 complex with glycerol (PDB code 4aow)

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3D Structures of receptor for activated protein kinase C 13D Structures of receptor for activated protein kinase C 1

Updated on 23-October-2017

3frx, 3rfg, 3rfh – yRACK1 – yeast
4aow – hRACK1 – human
1trj – yRACK1 + RNA – Cryo EM
4u3m, 4u3n, 4u3u, 4u4n, 4u4o, 4u4q, 4u4r, 4u4u, 4u4y, 4u4z, 4u50, 4u51, 4u52, 4u53, 4u55, 4u56, 4u6f, 4v88, 5dat, 5dc3, 5dge, 5dgf, 5dgv, 5fci, 5tga, 5tgm, 5fcj, 5i4l, 5mei, 5tbw, 5lyb - yRACK1 in 80S ribosome
3j6x, 3j6y, 4v6i, 4v7h, 4v7r, 3j77, 3j78, 4v8y, 4v8z, 5m1j, 5mc6, 5juo, 5jup, 5jus, 5jut, 5juu – yRACK1 in y80S ribosome – Cryo EM
4v6x, 5aj0, 4ug0, 5a2q, 5a2q, 5aj0, 5lks – hRACK1 in h80S ribosome – Cryo EM
5oa3, 5vyc - hRACK1 in 40S ribosome subunit - Cryo EM
5xyi - RACK1 in 20S ribosome subunit - Trichomonas vaginalis - Cryo EM
4bts, 4v50 - RACK1 in 40S ribosome subunit - Tetrahymena thermophila
4v92 - KlRACK1 in 80S ribosome - Kluyveromyces lactis - Cryo EM
5it9 - KlRACK1 in 26S ribosome subunit - Cryo EM
4uer - RACK1 in 40S ribosome subunit - Lachancea kluyveri - Cryo EM
5lzt, 5lzv, 5lzw, 4d5l, 5k0y, 5lzu, 5lzx, 5lzy, 5lzz, 4d61, 4ujc, 4ujd, 5lzs - rRACK1 in 80S ribosome - rabbit - Cryo EM
4kzx, 4kzy, 4kzz - rRACK1 in 40S ribosome subunit
5flx - rRACK1 in 40S ribosome subunit - Cryo EM
5t2a - RACK1 in 80S ribosome - Leishmania donovani - CryoEM
4v5z - RACK1 in 80S ribosome - dog - Cryo EM

ReferencesReferences

  1. ↑ Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ. RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol. 2007 Dec;27(23):8296-305. Epub 2007 Oct 1. PMID:17908799 doi:http://dx.doi.org/10.1128/MCB.00598-07
  2. ↑ Chang BY, Conroy KB, Machleder EM, Cartwright CA. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells. Mol Cell Biol. 1998 Jun;18(6):3245-56. PMID:9584165
  3. ↑ Nilsson J, Sengupta J, Frank J, Nissen P. Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep. 2004 Dec;5(12):1137-41. PMID:15577927 doi:http://dx.doi.org/10.1038/sj.embor.7400291
  4. ↑ Berns H, Humar R, Hengerer B, Kiefer FN, Battegay EJ. RACK1 is up-regulated in angiogenesis and human carcinomas. FASEB J. 2000 Dec;14(15):2549-58. PMID:11099474 doi:http://dx.doi.org/10.1096/fj.99-1038com
  5. ↑ Lin W, Zhang Z, Xu Z, Wang B, Li X, Cao H, Wang Y, Zheng SJ. The association of receptor of activated protein kinase C 1(RACK1) with infectious bursal disease virus viral protein VP5 and voltage-dependent anion channel 2 (VDAC2) inhibits apoptosis and enhances viral replication. J Biol Chem. 2015 Mar 27;290(13):8500-10. doi: 10.1074/jbc.M114.585687. Epub 2015, Jan 12. PMID:25583988 doi:http://dx.doi.org/10.1074/jbc.M114.585687

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