Mitogen-activated protein kinase

Function Mitogen-activated protein kinase (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, MAP2K and MAP3K which are activated by phosphorylation. MAPK1 or ERK2 and MAPK3 are activated in response to growth factors. For MAPK1 representations see Michael Roberts/BIOL115/ERK2. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8 (called also c-Jun N-terminal kinase 1 or JNK1), MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11 (also called p38-β MAPK), MAPK12 (also called p38-γ MAPK), MAPK13 (also called p38-δ MAPK), MAPK14 (also called p38-α MAPK) belongs to the class called p38 MAPK. Relevance MAPK cascade is elevated in cancer cells, hence MAPK inhibitors are tested as potential cancer therapy. Disease MAPK14 is associated with acquired hyperkeratosis and prostate transitional cell carcinoma. Structural highlights . Water molecule shown as red sphere.

spinqualitylabelsall models Human MAPK1 complex with inhibitor and sulfate (PDB entry 2ojg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Mitogen-activated protein kinase3D Structures of Mitogen-activated protein kinase

Updated on 23-July-2017

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• MAPK1
  • 4g6n, 4g6o, 4gsb – hMAPK1 - human
    
  • 3i5z, 3i60, 3w55, 2ojg, 2oji, 2ojj, 1wzy, 1tvo, 3sa0, 4fux, 4fuy, 4fv0, 4fv1, 4fv2, 4fv3, 4fv4, 4fv5, 4fv6, 4fv7, 4fv8, 4fv9, 4n4s, 4o6e, 4qp1, 4qp2, 4qp3, 4qp4, 4qp6, 4qp7, 4qp8, 4qp9 4qpa, 4qta, 4qte, 4xj0, 4xne, 4xoy, 4xoz, 4xp0, 4xp2, 4xp3, 4xrj, 4xrl, 4zzm, 4zzn, 4zzo, 5bue, 5bui, 5buj, 5bvd, 5bve, 5bvf, 5hd4, 5hd7, 5k4i, 5ke0, 5lcj, 5lck, 5ngu, 5nhf, 5nhh, 5nhj, 5nhl, 5nho, 5nhp, 5nhv, 5u6i – hMAPK1+inhibitor - human
    
  • 2y9q – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide
    
  • 3tei, 4h3p, 4nif – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1
    
  • 4iz5, 4iz7, 4iza – hMAPK1 (mutant) + astrocytic phosphoprotein
    
  • 4fmq – hMAPK1 + MAPK docking peptide
    
  • 4h3q – hMAPK1 + MAP2K 2 peptide
    
  • 5ax3 – hMAPK1 + allosteric inhibitor peptide
    
  • 4n0s – hMAPK1 + cafeic acid
    
  • 4zxt – hMAPK1 + catechol
    
  • 2z7l, 3c9w, 3qyw, 3qyz, 4qyy - rMAPK1+inhibitor – rat
    
  • 1erk, 4s31, 5umo - rMAPK1
    
  • 1gol, 3r63, 4s2z, 4s30 - rMAPK1 (mutant)
    
  • 2gph - rMAPK1 (mutant)+HEPTP (mutant)
    
  • 3o71 - rMAPK1 + colorectal cancer peptide
    
  • 2fys - rMAPK1 + KIM peptide
    
  • 4s32 – rMAPK1 + AMPPNP
    
  • 4s33, 4s34 – rMAPK1 (mutant) + AMPPNP
    
  • 4gt3, 4gva – rMAPK1 + nucleotide
    
  • 4i5h – rMAPK1 (mutant) + inhibitor
    
  • 3o71 - rMAPK1 + colorectal cancer peptide
    
  • 3zu7, 3zuv – rMAPK1 + ankyrin repeat protein
    
  • 2y4i – raMAPK1+kinase suppressor of RAS 2 – rabbit
    
  • 3oz6 - MAPK1 - Cryptosporidium parvum
• MAPK2
  • 1kwp – hMAPK2
    
  • 3gok - hMAPK2 kinase domain
    
  • 2pzy, 2p3g, 2jbo, 2jbp – hMAPK2 kinase domain +inhibitor
    
  • 3a2c, 3kc3, 3fpm, 3fyj, 3fyk, 3r2b, 3r2y, 3r30, 3wi6 - hMAPK2 kinase domain +inhibitor
    
  • 3m2w, 3kga, 3ka0, 3m42 – hMAPK2 kinase domain (mutant)+inhibitor
    
  • 2oza, 2onl – hMAPK2+ hMAPK14
    
  • 4tyh - hMAPK2+ hMAPK14 + inhibitor
    
  • 1nxk – hMAPK2 + staurosporine
    
  • 1ny3 – hMAPK2 + ADP
    
  • 2npt - hMAPK2 PHOX domain + hMAPK5
    
  • 2erk – rMAPK2
    
  • 3erk, 4erk – rMAPK2+inhibitor
    
• MAPK3
  • 2zoq – hMAPK3
    
  • 3r1n, 3she, 4qtb – hMAPK3 kinase domain +inhibitor
    
• MAPK6
  • 3fxw, 3fhr – hMAPK3 kinase domain +inhibitor
    
  • 2i6l – hMAPK6
    
• MAPK7

• • 4ic8 – hMAPK7
    
  • 4b99, 4zsg, 4zsj, 4zsl, 5byy, 5byz – hMAPK7+inhibitor
    
  • 4ic7 – hMAPK7+ MAP2K 5
    
• MAPK8
  • 3o17, 2gmx, 2g01, 3vud, 3vug, 3vuh, 3vui, 3vuk, 3vul, 3vum – hMAPK8 (mutant)+JIP1 peptide
    
  • 1ukh, 1uki - jMAPK8 JNK1+JIP1 peptide
    
  • 3v3v - hMAPK8 JNK1+JIP1 peptide + quercedagetin
    
  • 3o2m - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole
    
  • 2xrw, 2xs0 - hMAPK8 + NFAT peptide
    
  • 4ux9 – hMAPK8 + MAPKK7 peptide
    
  • 4yr8 – hMAPK8 + MKP7
    
  • 3elj, 3pze, 4awi, 4l7f, 4qtd - hMAPK8+inhibitor
    
  • 4e73, 4g1w, 4hys, 4hyu, 4izy – hMAPK8 + JIP1 +inhibitor
    
  • 2no3, 2h96 – hMAPK8 (mutant)+inhibitor
    
• MAPK9
  • 3e7o - hMAPK9 (mutant)
    
  • 3npc – hMAPK9 (mutant)+inhibitor
    
• MAPK10
  • 3kvx, 3fv8, 2waj, 3fi2, 3fi3, 3da6, 2zdt, 2zdu, 3cgf, 3cgo, 2r9s, 2o0u, 2o2u, 2exc, 2b1p, 1pmn, 4z9l, 1pmu, 1pmv, 3oy1, 2ok1, 3ttj, 3tti, 3rtp, 3v6r, 3v6s, 4kkh, 4u79, 4whz, 4x21, 4y46, 4y5h – hMAPK10+inhibitor
    
  • 3ptg, 4h39 - hMAPK10 catalytic domain + JIP1 peptide
    
  • 4h36 – hMAPK10 catalytic domain + ATF2 peptide
    
  • 4h3b – hMAPK10 catalytic domain + SAB peptide
    
  • 4kke, 4kkg – hMAPK10 catalytic domain + AMPPNP
    
  • 3g9l, 3g90, 3g9n, 2p33 – hMAPK10 catalytic domain+inhibitor
    
  • 3oxi - hMAPK10 + MAPK8 interacting protein + inhibitor
    
• MAPK11
  • 3gp0 – hMAPK11+inhibitor
    
  • 3gc8, 3gc9 – hMAPK11 (mutant)+inhibitor
    
• MAPK13
  • 3coi, 4yno, 4myg – hMAPK13
    
  • 4eyj, 4eym, 5ekn, 5eko - hMAPK13 +inhibitor
    
• MAPK14
  • 3mgy, 3mh0, 3mh1, 3mh2, 3mh3, 3hvc, 3npq, 1wbo, 1r39, 2npq, 1wfc, 1cm8, 5etc, 5eti, 5uoj – hMAPK14
    
  • 2lgc – hMAPK14 – NMR
    
  • 3od6, 3ody, 3odz, 3oef, 3p4k, 2fsl, 2fsm, 2fso, 2fst, 1r3c, 4e5a, 4geo – hMAPK14 (mutant)
    
  • 3new, 3ocg, 3mvl, 3mvm, 3nnu, 3nnv, 3nnw, 3nnx, 3nww, 3mpt, 3lhj, 3huc, 3itz, 3l8x, 3kf7, 3fi4, 3fkl, 3fkn, 3fko, 3fl4, 3fln, 3flq, 3fls, 3flw, 3fly, 3flz, 3fmh, 3fmj, 3fmk, 3fml, 3flm, 3fln, 3fsf, 3fsk, 3kq7, 3iph, 3hv4, 3hv5, 3hv6, 3hv7, 3k3i, 3hec, 3heg, 3gi3, 3hp2, 3hp5, 3hrb, 3ha8, 3gfe, 3hl7, 3hll, 3gcu, 3fc1, 3dt1, 3e92, 3e93, 3d7z, 3d83, 3ctq, 2puu, 3bx5, 3c5u, 2zaz, 2zb0, 2zb1, 2qd9, 2ewa, 2gfs, 2baj, 2bak, 2bal, 2baq, 1zyj, 1wbn, 1wbs, 1wbt, 1wbv, 1wbw, 1zz2, 1zzl, 1yqj, 1w7h, 1w82, 1w83, 1w84, 1oz1, 1ouk, 1ouy, 1m7q, 1kv1, 1kv2, 1di9, 2rg5, 2rg6, 3bv3, 3bv2, 3fmm, 3fmn, 3lfa, 3mw1, 3pg3, 3roc ,2yis, 2yiw, 2yix, 3qud, 3que, 3rin, 3s3i, 3s4q, 3u8w, 3uvp, 3uvq, 3uvr, 3zs5, 3zsg, 3zsh, 3zsi, 3zya, 4a9y, 4aa0, 4aa4, 4aa5, 4aac, 4dli, 4dlj, 4e5b, 4eh2, 4eh3, 4eh4, 4eh5, 4eh6, 4eh7, 4eh8, 4eh9, 4ehv, 4ewq, 4f9w, 4f9y, 4fa2, 4kin, 4kip, 4kiq, 4l8m, 4r3c, 4zth, 5lar, 5ml5, 5tbe, 5tco - hMAPK14+inhibitor
    
  • 4e6a, 4e6c, 4e8a - hMAPK14+ lipid
    
  • 3o8t, 3mpa, 3obg, 3o8u, 3o8p, 3obj, 3oc1, 3hub, 3l8s, 3hv3, 3iw5, 3iw6, 3iw7, 3iw8, 3k3j, 3gc7, 3gcp, 3gcq, 3gcs, 3gcv, 3ds6, 2i0h, 1ove, 3lfb, 3lfc, 3lfd, 3lfe, 3lff, 1bl6, 1bl7, 1bmk, 1a9u, 1ian - hMAPK14 (mutant)+inhibitor
    
  • 2y8o – hMAPK14 (mutant) + dual specificity MAP2K peptide
    
  • 4ka3, 4loo, 4lop, 4loq – hMAPK14 + docking peptide
    
  • 5eta – hMAPK14 + peptide
    
  • 3tg1 – hMAPK14 + MAPK phosphatase 5
    
  • 5etf – hMAPK14 + MAPKK 6
    
  • 2gtn, 2gtm, 3p5k, 3p78, 3p79, 3p7a, 3p7b, 3p7c - mMAPK14+inhibitor
    
  • 2ghm, 2ghl, 1ywr - mMAPK14 (mutant)+inhibitor
    
  • 3py3 - mMAPK14 phosphorylated
    
  • 1yw2, 1p38 - mMAPK14 (mutant)
    
  • 1lew - mMAPK14+MEF2A
    
  • 1lez - mMAPK14+MKK3B
    
• MAPK Fus3
  • 2f9g, 2b9f – yMAPK Fus3 – yeast
    
  • 2fa2 – yMAPK Fus3 (mutant)
    
  • 2f49 - yMAPK Fus3 +STE5 peptide
    
  • 2b9h, 2b9i - yMAPK Fus3 (mutant)+MSG5 peptide
    
  • 2b9j - yMAPK Fus3 (mutant)+FAR1 peptide
    
• MAPK
  • 3rp9 – MAPK – Toxoplasma gondii
    
  • 3uib – MAPK + inhibitor – Leishmania major