Undecaprenyl pyrophosphate synthase

Function Undecaprenyl pyrophosphate synthase (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall. Bisphosphonate drugs are UPP inhibitors. Relevance UPP inhibitors are investigated as potential antibacterials. Structural highlights The active site of UPP contains an . Water molecules shown as red spheres.

spinqualitylabelsall models Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of undecaprenyl pyrophosphate synthase3D structures of undecaprenyl pyrophosphate synthase

Updated on 23-March-2017

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• Undecaprenyl pyrophosphate synthase
  • 1f75 – UPP (mutant) – Micrococcus luteus
    
  • 3qas, 5cqb – EcUPP – Escherichia coli
    
  • 1jp3 – EcUPP (mutant)
    
  • 2d2r – HpUPP (mutant) – Helicobacter pylori
    
  • 2vg4 – MtUPP – Mycobacterium tuberculosis
    
  • 5kh2 – SpUPP – Streptococcus pneumoniae
    
• Undecaprenyl pyrophosphate synthase complexes
  • 1ueh – EcUPP + Mg + SO4 + triton
    
  • 1v7u – EcUPP + FPP
    
  • 1x06 – EcUPP + Mg + FPP analog + IPP
    
  • 1x08 – EcUPP (mutant) + Mg + FPP analog + IPP
    
  • 1x07 – EcUPP + Mg + PO4 + IPP
    
  • 1x09 – EcUPP (mutant) + Mg + IPP
    
  • 2e98, 2e99, 2e9a, 2e9c, 2e9d, 3th8, 3sgt, 3sgv, 3sgx, 3sh0, 4h2j, 4h2m, 4h2o, 4h38, 4h3c, 4h3a, 4h8e, 3wyj – EcUPP + bisphosphonate
    
  • 5cqj – EcUPP + inhibitor
    
  • 5kh4 – SpUPP + FPP
    
  • 5kh5 – SpUPP + inhibitor
    
  • 2dtn – HpUPP + pyrophosphate
    
  • 3ugs - UPP + FPP analog – Campylobacter jejuni
    
  • 2vg2 – MtUPP + Pi + PPi + methyl butenyl diphosphate
    
  • 2vg3 – MtUPP + Pi + Mg + geranyl diphosphate