WD repeat-containing protein

Function WD repeat-containing proteins (WDR) contain 4 or more repeating WD units. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). All WDRs form a β-propeller structure. WDRs have critical roles in many biological functions like signal transduction, transcription regulation and apoptosis. WD-repeat protein 5 (WDR5) contains 7 WD repeats. WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL). WD repeat-containing protein 48 and 20 act as regulators of deubiquinating complexes. Disease Mutant WDR is involved in triple-A syndrome. Structural highlights The histone Arg2 residue inserts into the central pore of the WDR5 β-propellor structure acting like an anchoring pin forming numerous hydrogen bonds and cation-π interactions.

spinqualitylabelsall models Human WD-repeat protein 5 (grey) complex with histone H3 peptide (green) (PDB code 2h9m) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of WD-repeat protein3D Structures of WD-repeat protein

Updated on 14-December-2016

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• WDR5
  • 2gnq, 2h68, 2h14, 2h9l – hWDR5 – human
    
  • [3mxx]], 3n0d, 3n0e – hWDR5 (mutant)
    
  • 3smr, 3ur4, 4ia9, 4qqe, 4ql1, 5eal, 5eam, 5eap, 5ear – hWDR5 + piperazine derivative
    
  • 2cnx, 2co0, 2h6k, 2h6n, 2h6q, 2h13, 2h9m, 2h9n, 2h9p, 2g99, 2g9a, 2o9k, 3psl, 4a7j – hWDR5 + histone H3 peptide
    
  • 3eg6, 3emh – hWDR5 + MLL1 peptide
    
  • 4gm3, 4gm8, 4gm9, 4gmb – hWDR5 + peptide inhibitor
    
  • 2xl2, 2xl3 – hWDR5 + retinoblastoma-binding protein 5 peptide
    
  • 4o45 – hWDR5 + influenza NS1 C-terminal
    
  • 4cy1 – hWDR5 + KAT8 regulatory NSL complex subunit 1+2 peptides
    
  • 4cy2 – hWDR5 + KAT8 regulatory NSL complex subunit 1 peptide
    
  • 4y7r – hWDR5 + Myc MbIIIb peptide
    
  • 3uvk, 3uvl, 3uvm, 3uvn, 3uvo, 4erq, 4ery, 4es0, 4esg, 4ewr, 5sxm – hWDR5 + MLL peptide
    
  • 4erz – hWDR5 + MLL4
    
  • 3p4f – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide
    
• WDR20
  • 5k19 – hWDR20
    
• WDR48
  • 5cvl – hWDR48
    
  • 5l8e – hWDR48 + peptide
    
  • 5l8w, 5cvn, 5cvo – hWDR48 + ubiquitin + ubiquitin carboxyl-terminal hydrolase
    
  • 5k1a, 5k1b – hWDR48 + ubiquitin carboxyl-terminal hydrolase
    
  • 5k1c – hWDR48 + WDR20 + ubiquitin carboxyl-terminal hydrolase