UvrABC

Function UvrABC endonuclease is an E. coli enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one. UvrA is the protein which locates the DNA damage. UvrB is involved in distinguishing damaged from undamaged DNA. The C-terminal region of UvrC is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair. For details on the UvrA-UvrB complex see UvrA-UvrB interaction domains. Structural highlights UvrA contains several domains: UvrB-binding, DNA-binding and two ATP-binding domains.

spinqualitylabelsall models UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) 3pih Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of UvrABC3D structures of UvrABC

Updated on 12-December-2016

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• UvrA
  • 3pih – TmUvrA + DNA – Thermotoga maritima
    
  • 3zqj – UvrA – Mycobacterium tuberculosis
    
  • 4dfc – EcUvrA + Transcription-repair-coupling factor – Escherichia coli
    
  • 2r6f – BstUvrA – Bacillus stearothermophilus
    
  • 3ux8 – GeUvrA - Geobacillus
    
• UvrB
  • 1d2m, 1c4o – UvrB – Thermus thermophilus
    
  • 1d9x – BcUvrB – Bacillus caldotenax
    
  • 1t5l – BcUvrB (mutant)
    
  • 1qoj – EcUvrB C terminal
    
  • 1e52 – EcUvrB C terminal - NMR
    
  • 1d9z – BcUvrB + ATP
    
  • 2fdc – BcUvrB + DNA
    
  • 2d7d, 2nmv, 3v4r – BsUvrB + DNA – Bacillus subtilis
    
• UvrC
  • 1kft – EcUvrC C terminal
    
  • 2nrr, 2nrt, 2nrv, 2nrw, 2nrx, 2nrz – TmUvrC C terminal
    
  • 1ycz, 1yd0, 1yd1 – TmUvrC N terminal
    
  • 1yd2, 1yd3, 1yd4, 1yd5 – TmUvrC N terminal (mutant)
    
  • 1yd6 – BcUvrC N terminal
    
  • 3c65 – BstUvrC
    
• UvrA-UvrB
  • 3fpn – BstUvrA + UvrB
    
  • 3uwx – GeUvrA + UvrB