TRAIL

Template:STRUCTURE 1d0g

TRAIL (TNF-related apoptosis-inducing ligand) functions as a ligand in the process of apoptosis^[1]. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see Molecular Playground/TRAIL.

3D Structures of TRAIL3D Structures of TRAIL

1d4v – hTRAIL + DR5 extracellular domain – human
1d0g - hTRAIL residues 114-281 + DR5 extracellular domain
1dg6 – hTRAIL jelly-roll domain
1d2q - hTRAIL extracellular domain

ReferencesReferences

↑ Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'En P, Xu XN, Jin BQ, Pezzella F, Screaton GR. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005 Jun;15(6):430-8. PMID:15987601 doi:http://dx.doi.org/10.1038/sj.cr.7290311

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'En P, Xu XN, Jin BQ, Pezzella F, Screaton GR. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005 Jun;15(6):430-8. PMID:15987601 doi:http://dx.doi.org/10.1038/sj.cr.7290311

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