Succinate-semialdehyde dehydrogenase

Function Succinate-semialdehyde dehydrogenase (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism. Disease SSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia.

spinqualitylabelsall models Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code 3vz3). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of succinate-semialdehyde dehydrogenase3D structures of succinate-semialdehyde dehydrogenase

Updated on 04-September-2016

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• Succinate-semialdehyde dehydrogenase
  • 4it9, 3vz1 – SySSD - Synechococcus
    
  • 3vz2 – SySSD (mutant)
    
  • 3ifg, 3ifh – SSD – Burkholderia pseudomallei
    
  • 3rh9 – SSD – Marinobacter aquaeolei
    
  • 2w8n, 2w8o – hSSD - human
    
  • 2w8p – hSSD (mutant)
    
  • 4ogd – SpSSD – Streptococcus pyogenes
    
• Succinate-semialdehyde dehydrogenase complexes
  • 2w8q – hSSD (mutant) + succinate
    
  • 2w8r – hSSD (mutant) + ADP
    
  • 4ita – SySSD + NADPH
    
  • 4itb – SySSD + NADPH + succinic semialdehyde
    
  • 3vz3 – SySSD (mutant) + NADPH + succinic semialdehyde
    
  • 3jz4 – SSD + NADPH – Escherichia coli
    
  • 4oht – SpSSD + NADPH
    
  • 4ywu, 4ywv – SySSD + oxobutanoic acid + succinic semialdehyde