Spermidine Synthase

Under construction! Function Polyamines are essential in all branches of life. Spermidine synthase (putrescine aminopropyltransferase, PAPT) (SPS) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine. 1inl - The crystal structure of the PAPT from Thermotoga maritima (TmPAPT) has been solved to 1.5 A resolution. The structure of TmPAPT in a complex with adoDATO (1jq3) can also be found on this site. Structural highlights SPS active sited contains the substrate spermidine.

spinqualitylabelsall models Structure of human spermidine synthase complex with spermidine and deoxymethyladenosine (PDB entry 3c6k) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of spermidine synthase3D structures of spermidine synthase

Updated on 30-August-2016

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• Spermidine synthase
  • 1inl – TmSPS – Thermotoga maritima
    
  • 1mjf – SPS – Pyrococcus furiosus
    
  • 2e5w, 2zsu - SPS – Pyrococcus horikishii
    
  • 1iy9 – SPS – Bacillus subtilis
    
  • 1xj5, 2q41 – SPS – Arabidopsis thaliana
    
  • 2b2c – SPS – Caenorhabditis elegans
    
  • 2o05, 2o06, 2o07, 2o0l – SPS – human
    
  • 2cmg, 2cmh – SPS – Helicobacter pylori
    
  • 2pss – PfSPS – Plasmodium falciparum
    
  • 3o4f – SPS – Escherichia coli
    
  • 3bwc - TcSPS – Trypanosoma cruzi
    
• Binary complexes of spermidine synthase
  • 1jq3 – TmSPS + transition state analog
    
  • 2hte, 2pt6 - PfSPS + methylthioadenosine
    
  • 2i7c - PfSPS + transition state analog
    
  • 2pwp - PfSPS + spermidine
    
  • 3b7p - PfSPS + spermine
    
  • 3bwc - TcSPS + SAM
    
  • 3rw9 - hSPS + SAH
    
  • 3anx – SPS + methylthioadenosine – Thermus thermophilus
    
• Ternary complexes of spermidine synthase
  • 3c6k - hSPS + methylthioadenosine + spermidine
    
  • 3c6m - hSPS + methylthioadenosine + spermine
    
  • 2pt6, 3rie - PfSPS + inhibitor + methylthioadenosine
    
  • 2pt9 - PfSPS + inhibitor + SAM derivative
    

ReferencesReferences

Created with the participation of Lindsey Butler.