NADPH dehydrogenase

Function

NADPH dehydrogenase or old yellow enzyme (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor^[1]. See NAD(P)H. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN.

Structural highlights

OYE cofactor FMN interacts with the ligand^[2].

Structure of yeast NADPH dehydrogenase complex with FMN and p-hydroxybenzaldehyde (PDB code 1oyb).

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3D Structures of NADPH dehydrogenase3D Structures of NADPH dehydrogenase

Updated on 05-May-2016

ReferencesReferences

↑ Ryu JY, Suh KH, Chung YH, Park YM, Chow WS, Park YI. NADPH dehydrogenase-mediated respiratory electron transport in thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803 is inactive in the light. Mol Cells. 2003 Apr 30;15(2):240-4. PMID:12803488
↑ Brown BJ, Hyun JW, Duvvuri S, Karplus PA, Massey V. The role of glutamine 114 in old yellow enzyme. J Biol Chem. 2002 Jan 18;277(3):2138-45. Epub 2001 Oct 19. PMID:11668181 doi:10.1074/jbc.M108453200

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Michal Harel, Alexander Berchansky

[1] Ryu JY, Suh KH, Chung YH, Park YM, Chow WS, Park YI. NADPH dehydrogenase-mediated respiratory electron transport in thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803 is inactive in the light. Mol Cells. 2003 Apr 30;15(2):240-4. PMID:12803488

[2] Brown BJ, Hyun JW, Duvvuri S, Karplus PA, Massey V. The role of glutamine 114 in old yellow enzyme. J Biol Chem. 2002 Jan 18;277(3):2138-45. Epub 2001 Oct 19. PMID:11668181 doi:10.1074/jbc.M108453200

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