NADPH dehydrogenase

Function NADPH dehydrogenase or old yellow enzyme or NADH:flavin oxidoreductase/NADH oxidase or prostaglandin F2A synthase or chromate reductase (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor. See NAD(P)H. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. NADPH dehydrogenase quinone 1 (NQO1) reduces quinones to hydroquinones. NADPH dehydrogenase quinone 2 (NQO2) catayzes electron transfer from NADH to ubiquinone in the mitochondrial respiratory chain. Structural highlights . Water molecules are shown as red spheres.

spinqualitylabelsall models Structure of yeast NADPH dehydrogenase complex with FMN, p-hydroxybenzaldehyde and Mg+2 ion (green) (PDB code 1k03). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of NADPH dehydrogenase3D Structures of NADPH dehydrogenase

Updated on 15-July-2024

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• NADPH dehydrogenase
  • 7blf – OYE + FMN - fungus
    
  • 1oyc, 1oya – yOYE + FMN - yeast
    
  • 1oyb – yOYE + FMN + p-hydroxybenzaldehyde
    
  • 3tjl – SsOYE + FMN + malonate - Scheffersomyces stipitis
    
  • 6s32 – OYE + FMN + benzamidine – Chroococcidiopsis thermalis
    
  • 6s31 – GsOYE + FMN + benzaldehyde – Galdieria sulphuraria
    
  • 6s0g, 6s23 – GsOYE + FMN
    
  • 6agz – OYE + FMN - Pichia
    
  • 3kru, 3krz – OYE + FMN – Thermoanaerobacter pseudethanolicus
    
  • 3atz – TcOYE + FMN + benzaldehyde – Trypanosoma cruzi
    
  • 3aty – TcOYE + FMN
    
  • 2gou, 2gqa – SoOYE + FMN – Shewanella oneidensis
    
  • 2gq9 – SoOYE + FMN + benzaldehyde
    
  • 7o0t – OYE + FMN – Chloroflexus aggregans
    
  • 3hgj – TsOYE + FMN + benzaldehyde – Thermus scotoductus
    
  • 3hf3 – TsOYE + FMN
    
• NADPH dehydrogenase 1
  • 4rnu, 4rnw, 4rnx – yOYE 1 + FMN
    
  • 1k02, 4h6k, 4k7y – yOYE 1 (mutant) + FMN
    
  • 1bwk, 1bwl – OYE 1 (mutant) + FMN - Candida albicans
    
  • 3gr7, 3gr8 – OYE + FMN – Geobacillus kaustophilus
    
  • 4rnv, 5v4p – yOYE 1 + FMN + p-hydroxybenzaldehyde
    
  • 1k03 – yOYE 1 (mutant) + FMN + p-hydroxybenzaldehyde
    
  • 3rnd – yOYE 1 mutant) + FMN + hydroxymethyl cyclopent-2-en-one
    
  • 4yil, 4ync – yOYE 1 (mutant) + FMN + acrylate derivative
    
  • 4gbu, 4gxm – yOYE 1 (mutant) + FMN + methyl propenyl phenol
    
  • 4ge8, 3txz, 4gwe, 4h4i, 4k7v, 4k8e, 4k8h – yOYE 1 (mutant) + FMN + carvone
    
  • 3tx9 – yOYE 1 + FMN + hydroxymethyl cyclopent-2-en-one
    
• NADPH dehydrogenase 2.6
  • 4qai – SsOYE 2.6 (mutant) + FMN
    
  • 4m5p – SsOYE 2.6 + FMN + malonate
    
  • 3upw – SsOYE 2.6 + FMN + malonate + nicotineamide
    
  • 4df2 – SsOYE 2.6 + FMN + malonate + chlorophenol
    
• NADPH dehydrogenase 3
  • 5v4p – yOYE 3 + FMN + p-hydroxybenzaldehyde
    
  • 5v4v – yOYE 3 + FMN + nicotinamide
    
• NADPH dehydrogenase 4
  • 4b5n – SoOYE 4 + FMN
    
• NADPH dehydrogenase quinone 1
  • 5a4k – hNQO1 (mutant) + FAD - human
    
  • 5fuq, 4cet – hNQO1 (mutant) + FAD + dicoumarol
    
  • 4cf6 – hNQO1 (mutant) + FAD + cibacron blue