Interleukin-1 receptor-associated kinase

FunctionFunction

Interleukin-1 receptor-associated kinase (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins.

RelevanceRelevance

IRAK4 is involved in early recognition of pathogens and the initiation of inflammation when fighting infection.

DiseaseDisease

IRAK4 deficiency is a disorder which causes recurrent bacterial infections.

3D structures of IRAK43D structures of IRAK4

Updated on 30-March-2016

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• IRAK2
  • 3mop – hIRAK2 DEATH domain + hIRAK4 DEATH domain + MYD88 - human
    
• IRAK4
  • 2nru, 2nry, 2oib, 2o8y – hIRAK4 kinase domain - human
    
  • 4u97, 4u9a - hIRAK4 kinase domain (mutant)
    
  • 1wh4 – mIRAK4 DEATH domain – mouse – NMR
    
  • 2a9i - mIRAK4 DEATH domain
    
  • 2oic, 4xs2 - hIRAK4 kinase domain + staurosporine
    
  • 4y73, 4yo6, 4yp8, 4ztl, 4ztm, 4ztn - hIRAK4 kinase domain + inhibitor
    
  • 2oid - hIRAK4 kinase domain + AMPPNP