Interleukin-1 receptor-associated kinase

Function Interleukin-1 receptor-associated kinase (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins. Interleukin-1 receptor-associated kinase 1 (IRAK1) is a key link in the chain of events initiated by the binding of ligands to IL-R and Toll-like receptor . Interleukin-1 receptor-associated kinase 2 (IRAK2) is involved in ER stress-induced cell death. Interleukin-1 receptor-associated kinase 3 (IRAK3) is a critical modulator of inflammation in innate immunity. Interleukin-1 receptor-associated kinase 4 (IRAK4) has scaffold function in myddosome formation . Relevance IRAK4 is involved in early recognition of pathogens and the initiation of inflammation when fighting infection. Disease IRAK4 deficiency is a disorder which causes recurrent bacterial infections.

spinqualitylabelsall models Mouse IRAK4 death domain complex with Mn+2 ion , 2a9i Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of interleukin-1 receptor-associated kinase3D structures of interleukin-1 receptor-associated kinase

Updated on 07-July-2024

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• IRAK1
  • 6bfn – hIRAK1 residues 194-530 - human
    
• IRAK2
  • 3mop – hIRAK2 DEATH domain + hIRAK4 DEATH domain + MYD88
    
• IRAK3; Domains – DEATH 4-106; pseudokinase 145-454
  • 5uke – hIRAK3 DEATH domain (mutant) - NMR
    
  • 6ziw – hIRAK3 pseudokinase domain + ATPgS
    
  • 6ruu – hIRAK3 pseudokinase domain
    
• IRAK4 kinase domain residues 30-336; DEATH domain residues 4-106
  • 2nru, 2nry, 2oib, 2o8y, 4rmz – hIRAK4 kinase domain
    
  • 4u97, 4u9a - hIRAK4 kinase domain (mutant)
    
  • 2oic, 4xs2 - hIRAK4 kinase domain + staurosporine
    
  • 4y73, 4yo6, 4yp8, 4ztl, 4ztm, 4ztn, 5kx7, 5kx8, 5t1s, 5t1t, 5uiq, 5uir, 5uis, 5uit, 5uiu, 6f3d, 6f3e, 6f3g, 6f3i, 6lxy, 6n8g, 6o8u, 6o94, 6o95, 6o9d, 6thw, 6thx, 6thz, 6ti8, 6tia, 6uya, 6vql, 7c2v, 7c2w, 7og1, 7qg2, 7qg3, 7qg5, 8dks - hIRAK4 kinase domain + inhibitor
    ,
  • 5w84, 5w85, 5k72, 5k75, 5k76, 5k7g, 5k7i, 6ega, 6eg9, 6egd, 6ege, 6egf, 6mom, 6rfi, 6rfj - hIRAK4 residues 154-460 + inhibitor
    
  • 2oid - hIRAK4 kinase domain + AMPPNP
    
  • 3mop - hIRAK4 DEATH domain + hIRAK2 DEATH domain + MYD88
    
  • 1wh4 – mIRAK4 DEATH domain – mouse – NMR
    
  • 2a9i - mIRAK4 DEATH domain