Geranylgeranyl pyrophosphate synthase
FunctionFunction
Geranylgeranyl pyrophosphate synthase (GGPPS) catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate and isopentenyl diphosphate. GGPPS is involved in the addition of hydrophobic molecules to proteins and in the regulation of a nuclear hormone receptor.
RelevanceRelevance
GGPPS inhibitors are studied as therapeutical targets since geranylgeranylation is a post-translational modification of several proteins involved in human disease[1].
3D Structures of geranylgeranyl pyrophosphate synthase3D Structures of geranylgeranyl pyrophosphate synthase
Updated on 06-March-2016
2dh4 – yGGPPS + Mg - yeast
2e8t – yGGPPS + Mg + isopentenyl pyrophosphate + farnesyl thiopyrophosphate
2e8u, 2e8w – yGGPPS + Mg + isopentenyl pyrophosphate
2e8v – yGGPPS + GGPP
2z4v – yGGPPS + GGPP + Mg
2e8x – yGGPPS + GPP + Mg
2e90 – yGGPPS + Mg + PP + farnesyl pyrophosphate
2e91, 2e92, 2e93, 2e94, 2e95, 2z7h, 2z4w, 2z4x, 2z4y, 2z4z, 2z50, 2z52, 2z78, 2z7i, 2zeu – yGGPPS + Mg + inhibitor
2zev – yGGPPS + Mg + isopentenyl pyrophosphate + inhibitor
2q80 – GGPPS + GGPP + Mg - human
2azj – SsGGPPS – Sulfolobus solfataricus
2azk – SsGGPPS (mutant)
3lk5, 3lmd – CgGGPPS – Corynebacterium glutamicum
3q2q – CgGGPPS + Ca + isoprenyl diphosphate
3qqv – CgGGPPS + Mg + isoprenyl diphosphate
3n3d, 3pko – GGPPS – Lactobacillus brevis
2j1o – SaGGPPS – Sinapis alba
2j1p – SaGGPPS + GGPP
ReferencesReferences
- ↑ Wiemer AJ, Wiemer DF, Hohl RJ. Geranylgeranyl diphosphate synthase: an emerging therapeutic target. Clin Pharmacol Ther. 2011 Dec;90(6):804-12. doi: 10.1038/clpt.2011.215. Epub 2011, Nov 2. PMID:22048229 doi:http://dx.doi.org/10.1038/clpt.2011.215