Thymidylate kinase

Thymidylate kinase (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. The TMK inhibitor azido-dTMP (AZTP) is an HIV AZT prodrug metabolite. For more details see Student Project 8 for UMass Chemistry 423 Spring 2015.

3D Structures of thymidylate kinase3D Structures of thymidylate kinase

Updated on 22-February-2016

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• Thymidylate kinase
  • 2cck, 4f4i – SaTMK – Staphylococcus aureus
    
  • 2pbr – TMK – Aquifex aeolicus
    
  • 2plr – TMK – Sulfolobus tokodaii
    
  • 3ld9 – TMK – Ehrlichia chafeensis
    
  • 3v9p – TMK – Burkholderia thailandensis
    
  • 3uwk, 3uwo – PaTMK – Pseudomonas aeruginosa
    
• Thymidylate kinase complex with HIV prodrug AZT derivative
  • 2tmk – yTMK + AZTP
    
  • 4eaq – SaTMK + AZTP
    
  • 4gmd – PaTMK + AZTP
    
  • 4tmk, 5tmp – TMK + AZTP – Escherichia coli
    
  • 1w2h – MtTMK + AZTP - Mycobacterium tuberculosis
    
  • 1e98, 1e99, 1e9d – hTMK (mutant) + AZTP + ADP
    
• Thymidylate kinase complex with nucleotides
  • 2v54 – VvTMK + TDP – Vaccinia virus
    
  • 2w0s – VvTMK + brivudin-MP
    
  • 1tmk – yTMK + dTMP - yeast
    
  • 4e5u – PaTMK + dTMP
    
  • 2ccg, 2ccj, 4dwj – SaTMK + dTMP
    
  • 1g3u, 1gsi, 1n5i, 1n5k – MtTMK + dTMP
    
  • 1w2g – MtTMK + thymidine
    
  • 1gtv – MtTMK + TDP
    
  • 1n5j – MtTMK + TDP + TTP
    
  • 1n5l – MtTMK + TDP + dTMP
    
  • 1mrs – MtTMK + UMP derivative
    
  • 3uxm, 4esh – PaTMK + deoxy thymidine derivative
    
  • 3hjn – TMK + ADP + TDP – Thermotoga maritima
    
  • 1e2d, 1e2e, 1e2f, 1e9e, 1e9f – hTMK (mutant) + ADP + dTMP - human
    
  • 1e9f – hTMK (mutant) + ADP + dTMP - human
    
  • 4edh – PaTMK + ADP + dTMP
    
  • 3lv8 – VcTMK + ADP + dTMP + TDP – Vibrio cholerae
    
  • 3n2i – VcTMK + thymidine + thymidine deoxy-thymidine
    
  • 1e9b – hTMK (mutant) + azido-TMP + APPNP
    
  • 1e9c – hTMK (mutant) + dTMP + APPNP
    
  • 1nmx – hTMK (mutant) + F-TMP + ADP
    
  • 1nmy, 1nn0, 1nnz, 1nn1, 1nn3, 1nn5, 1nmz – hTMK (mutant) + dTMP derivative + APPNP
    
  • 2xx3 – hTMK + dTMP derivative + ADP
    
  • 2yof, 2yog, 2yoh - TMK + thymidine analog – Plasmodium falciparum
    
• Other thymidylate kinase binary complexes
  • 4gfd, 4hlc, 4hld, 4hej, 4hdc – SaTMK + antibacterial drug
    
  • 4gsy, 4qg7, 4xwa – SaTMK + inhibitor
    
  • 4qg7, 4qgf, 4qgg, 4qgh – SaTMK (mutant) + inhibitor
    
  • 4mqb – SaTMK + MES
    
  • 4unp – MtTMK + inhibitor
    
• Thymidylate kinase complex with bisubstrate inhibitor
  • 1mrn – MtTMK + TP5A
    
  • 3tmk – yTMK + TP5A
    
  • 1e9a – hTMK (mutant) + azido-TP5A + ADP