NAD kinase (NADK) catalyzes the conversion of ATP and NAD to ADP and NADP. NADP is critical for metabolism, calcium signaling and anti-inflammatory processes. NADK is regulated by calmodulin-dependent mechanism.
FunctionDiseaseRelevanceStructural highlights | |
3D structures of NAD kinase3D structures of NAD kinase
Updated on 07-January-2016
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- NAD kinase
- 1u0r, 1u0t – MtNADK – Mycobacterium tuberculosis
- 1y3h – MtNADK (mutant)
- 1yt5 – NADK – Thermotoga maritima
- 2i1w – LmNADK – Listeria monocytogenes
- 4hao – NADK – Yersinia pestis
- NAD kinase complex
- 1y3i – MtNADK + NAD
- 1z0s – AfNADK + ATP + PPi – Archaeoglobus fulgidus
- 1z0u – AfNADK + NADP
- 1z0z – AfNADK + NAD
- 2i29 – LmNADK + NAD
- 2i2a – LmNADK + NADP
- 2i2b, 2i2c, 2i2d, 4dy6, 3v7u, 3v7w, 3v7y, 3v80, 3v8m, 3v7n, 3v7p – LmNADK + adenosine derivative
- 2q5f, 3v8q, 3v8r – LmNADK (mutant) + adenosine derivative
- 2i2f – LmNADK (mutant) + NAD + Pi
ReferencesReferences
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