NAD kinase

Function NAD kinase or ATP-dependent NAD kinase (NADK) catalyzes the conversion of ATP and NAD to ADP and NADP. NADP is critical for metabolism, calcium signaling and anti-inflammatory processes. NADK is regulated by calmodulin-dependent mechanism. See NAD and NAD(P)H. Structural highlights in a cleft between the N and C-terminal domains in the dimer interface. Water molecules are shown as red spheres.

spinqualitylabelsall models NAD kinase complex with NADP and sulfate (PDB code 1z0u) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of NAD kinase3D structures of NAD kinase

Updated on 11-July-2023

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• NAD kinase
  • 3pfn, 7r4j – hNADK catalytic domain 61-442 – human
    
  • 1u0r, 1u0t – MtNADK – Mycobacterium tuberculosis
    
  • 1y3h – MtNADK (mutant)
    
  • 1yt5 – NADK – Thermotoga maritima
    
  • 2i1w – LmNADK – Listeria monocytogenes
    
  • 5ejf, 5ejg, 5ejh – LmNADK (mutant)
    
  • 4hao – NADK – Yersinia pestis
    
  • 3pfn – NADK – human
    
• NAD kinase complex
  • 7r4k, 7r4l, 7r4m – hNADK 2 catalytic domain + NADP
    
  • 7n29 – hNADK 2 catalytic domain + NAD
    
  • 1y3i – MtNADK + NAD
    
  • 1z0s – AfNADK + ATP + PPi – Archaeoglobus fulgidus
    
  • 1z0u – AfNADK + NADP
    
  • 1z0z – AfNADK + NAD
    
  • 2i29 – LmNADK + NAD
    
  • 2i2a – LmNADK + NADP
    
  • 2i2b, 2i2c, 2i2d, 4dy6, 3v7u, 3v7w, 3v7y, 3v80, 3v8m, 3v8n, 3v8p, 5dhp, 5dhq, 5dhr, 5dhs, 5dht, 5dhu, 6z61, 6z64, 6z65, 7zz7, 7zz9, 7zza, 7zzb, 7zzc, 7zzd, 7zze, 7zzg, 7zzh, 7zzj, 8a9v, 8b47 – LmNADK + adenosine derivative inhibitor
    
  • 2q5f, 3v8q, 3v8r – LmNADK (mutant) + adenosine derivative
    
  • 6rbo, 6rbp, 6rbq, 6rbr, 6rbs, 6rbt, 6rbu, 6rbv, 6rbw, 6rbx, 6rby, 6rbz, 6rc0, 6rc1, 6rc2, 6rc3, 6rc4, 6rc5, 6rc6, 6rr2 – LmNADK + adenine derivative
    
  • 6rg6, 6rg7, 6rg8, 6rg8, 6rg9, 6rga, 6rgb, 6rgc, 6rgd, 6rge, 6rgf – LmNADK + inhibitor
    
  • 2i2f – LmNADK (mutant) + NAD + Pi
    
  • 5eji – LmNADK (mutant) + NADP + PPi
    
  • 7mh7, 7qvs – NADK + NADP – Pseudomonas aeruginosa