Dethiobiotin synthetase (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.[1]
Structural highlightsThe .[2]
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3D dethiobiotin synthetase3D dethiobiotin synthetase
Updated on 29-December-2015
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- DTBS
- 1dbs, 1dts, 1byi – EcDTBS – Escherichia coli
- 2qmo – HpDTBS – Helicobacter pylori
- 3fgn – MtDTBS – Mycobacterium tuberculosis
- 3of5 – DTBS – Francicella tularensis
- DTBS binary complex
- 3fmf – MtDTBS + DAN
- 1dad – EcDTBS + ADP
- 1dae - EcDTBS + nonanedioate derivative
- 3fmi – MtDTBS + aminopelargonic acid
- 1dai - EcDTBS + DAN
- DTBS ternary complex
- 3qxc - HpDTBS + Mg + ATP
- 1daf - EcDTBS + DAN + ADP
- 1dag - EcDTBS + DAN + ATP derivative
- 3qxj - HpDTBS + Mg + ATP
- 3qxs - HpDTBS + Mg + phosphoaminophosphonic acid
- DTBS quaternary complex
- 1dah - EcDTBS + DAN + Mn + ATP derivative
- 1bs1 - EcDTBS + DTB + Mg + ADP
- 1a82 - EcDTBS + DAN + Mg + ATP
- 3fpa - MtDTBS + DTB + Mg + phosphate
- 3mle - HpDTBS + Mg + phosphate + ADP
- 3qy0 - HpDTBS + Mg + phosphate + GDP
- DTBS higher complexes
- 1dam - EcDTBS + DTB + Mg + phosphate + ADP
- 1dak - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP
- 3qxh - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP
- 3qxx - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP
ReferencesReferences
- ↑ Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568
- ↑ Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910