Dethiobiotin synthetase

Dethiobiotin synthetase (DTBS) or ATP-depenent dethiobiotin synthetase catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.^[1]

Structural highlights

The .^[2]

3D dethiobiotin synthetase

Dethiobiotin synthetase 3D structures

Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry 1a82)

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ReferencesReferences

↑ Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568
↑ Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910

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Michal Harel, Alexander Berchansky

[1] Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568

[2] Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910

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