Dethiobiotin synthetase

Dethiobiotin synthetase (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate. Structural highlights The active site contains the substrate, Mg+2 ion and ADP.

spinqualitylabelsall models Dethiobiotin synthetase complex with dethiobiotin, ADP (stick model) and Mg+2 ion (green) (PDB entry 1a82) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D dethiobiotin synthetase3D dethiobiotin synthetase

Updated on 24-December-2015

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• DTBS
  • 1dbs, 1dts, 1byi – EcDTBS – Escherichia coli
    
  • 2qmo – HpDTBS – Helicobacter pylori
    
  • 3fgn – MtDTBS – Mycobacterium tuberculosis
    
  • 3of5 – DTBS – Francicella tularensis
• DTBS binary complex
  • 3fmf – MtDTBS + DAN
    
  • 1dad – EcDTBS + ADP
    
  • 1dae - EcDTBS + nonanedioate derivative
    
  • 3fmi – MtDTBS + aminopelargonic acid
    
  • 1dai - EcDTBS + DAN
• DTBS ternary complex
  • 3qxc - HpDTBS + Mg + ATP
    
  • 1daf - EcDTBS + DAN + ADP
    
  • 1dag - EcDTBS + DAN + ATP derivative
    
  • 3qxj - HpDTBS + Mg + ATP
    
  • 3qxs - HpDTBS + Mg + phosphoaminophosphonic acid
• DTBS quaternary complex
  • 1dah - EcDTBS + DAN + Mn + ATP derivative
    
  • 1bs1 - EcDTBS + DTB + Mg + ADP
    
  • 1a82 - EcDTBS + DAN + Mg + ATP
    
  • 3fpa - MtDTBS + DTB + Mg + phosphate
    
  • 3mle - HpDTBS + Mg + phosphate + ADP
    
  • 3qy0 - HpDTBS + Mg + phosphate + GDP
    
• DTBS higher complexes
  • 1dam - EcDTBS + DTB + Mg + phosphate + ADP
    
  • 1dak - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP
    
  • 3qxh - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP
    
  • 3qxx - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP