Complexin

Function

Complexin (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.^[1]

Structural highlights

CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin.

Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry 3rk3)

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3D structures of complexin3D structures of complexin

Updated on 14-December-2015

1kil – CPLX + SNARE – rat

3rk3, 3rl0 - CPLX + SNARE – human

ReferencesReferences

↑ Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002 Nov 1;277(44):41652-6. Epub 2002 Aug 27. PMID:12200427 doi:http://dx.doi.org/10.1074/jbc.M205044200

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002 Nov 1;277(44):41652-6. Epub 2002 Aug 27. PMID:12200427 doi:http://dx.doi.org/10.1074/jbc.M205044200

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