Complexin

Function

Complexin (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.^[1]

Structural highlights

(PDB entry 3rk3).^[2]

Human complexin (magenta) as part of the SNARE complex (VAMP2 - cyan; syntaxin - green; SNAP25 (pink and yellow) (PDB entry 3rk3)

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3D structures of complexin3D structures of complexin

Updated on 07-July-2020

3rk3, 3rl0 - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human
1kil – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat
5w5c, 5w5d - rCPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin

ReferencesReferences

↑ Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002 Nov 1;277(44):41652-6. Epub 2002 Aug 27. PMID:12200427 doi:http://dx.doi.org/10.1074/jbc.M205044200
↑ Kummel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM. Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101. PMID:21785414 doi:10.1038/nsmb.2101

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002 Nov 1;277(44):41652-6. Epub 2002 Aug 27. PMID:12200427 doi:http://dx.doi.org/10.1074/jbc.M205044200

[2] Kummel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM. Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101. PMID:21785414 doi:10.1038/nsmb.2101

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