Cyclin-dependent kinase regulatory subunit

Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal diferentiation. CKS exists as hexamer of homodimers and can bind six kinase molecules.

spinqualitylabelsall models Human CKS-1 complex with phosphate (PDB code 1dks) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of cyclin-dependent kinase regulatory subunit3D Structures of cyclin-dependent kinase regulatory subunit

Updated on 14-October-2015

{"openlevels":0}

• CKS
  • 4lpa, 1qb3 – yCKS 1 - yeast
    
  • 3qy2 – yCKS 1 (mutant)
    
  • 1puc, 1sce – fyCKS 1 – fission yeast
    
  • 1dks, 1dkt – hCKS 1 - human
    
  • 1cks – hCKS 2
    
• CKS complexes
  • 4yc6 – hCKS 1 + CDK1
    
  • 1buh – hCKS 1 + CDK2
    
  • 1h4l, 1ung – hCKS 1 + CDK5
    
  • 1unh, 1unl – hCKS 1 + CDK5 + inhibitor
    
  • 3o0g – hCKS 1 + CDK5 + ATP analog
    
  • 2ass – hCKS 1 + Skp1 + Skp2
    
  • 2ast – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide
    
  • 4y72 – hCKS 2 + cyclin B1 + CDK1