RING box protein

RING box protein (RBX) makes a heterodimer with cullin. The heterodimer is essential for the protein ubiquitination process. RBX1 is a component of the SCF (Skp1-cullin-F box protein) E3 ubiquitin ligase complex. RBX contains a RING-type zinc finger domain. The RING domain is 40 to 60 residues long and binds two Zn atoms. It is involved in protein-protein interaction.

spinqualitylabelsall models Human RING finger protein 1 complex with cullin-1 and glomulin (PDB code 4f52) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of RING box protein3D Structures of RING box protein

Updated on 09-July-2015

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• Ring box protein 1
  • 2lgv – hRBX1 residues 12-108 (mutant) – human - NMR
    
  • 1ldj – hRBX1 + hCullin-1
    
  • 3rtr – hRBX1 + hCullin-1 residues 411-766 (mutant)
    
  • 1ldk – hRBX1 + hCullin-1 + cyclin A/Cdk2-asociated protein + Skp2-like protein
    
  • 1u6g – hRBX1 + hCullin-1 + TIP120 protein
    
  • 4f52 – hRBX1 + hCullin-1 residues 411-690 (mutant) + glomulin
    
  • 4p5o – hRBX1 + hCullin-1 residues 411-776 + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 + NEDD8-conjugating enzyme Ubc12 + NEDD8
    
  • 2hye – hRBX1 + hCullin-4A + DNA damage-binding protein 1 + nonstructural protein
    
  • 4a0k – hRBX1 + hCullin-4A + DNA damage-binding protein 1 + DNA damage-binding protein 2 + DNA
    
  • 3dpl – hRBX1 + hCullin-5 residues 401-780 (mutant)
    
  • 3dqv – hRBX1 + hCullin-5 residues 401-780 (mutant) + NEDD8
    
  • 4a0c – hRBX1 + hCullin-4B residues 192-913 + Cullin-associated NEDD8-dissociated protein
    
  • 4a0l – hRBX1 + hCullin-4B + DNA damage-binding protein 1 + DNA damage-binding protein 2 + DNA
    
• Ring box protein 2
  • 2ecl – hRBX2 RING domain - NMR