Actin

Actin is a protein found in all eukaryotic cells. It is the monomer of two types of filaments: microfilaments which are part of the cytoskeleton and thin filaments which are part of muscles. Three isoforms of actin are identified: α (Aa) (or G-actin) found in muscle tissue, β (Ab) and γ (Ag) actins are components of the cytoskeleton. F-actin is Aa bound to ATP. The images at the left and at the right correspond to one representative Actin, i.e. the crystal structure of rabbit Native G-actin (3hbt). For more details see:
*F-actin
*Non-polymerizable monomeric actin.
(PDB entries 1hlu and 2btf; morph was taken from Gallery of Morphs of the Yale Morph Server).

3D Structures of Actin3D Structures of Actin

Updated on 21-January-2015

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• α actin 1 (Aa)
  • 2w49 – cAa +troponin C+ troponin T+ troponin I+ tropomyosin α-1 – chicken
    
  • 3j4k - cAa + tropomyosin
    
  • 1mdu – cAa+hGelsolin
    
  • 3j8a - mAa + tropomyosin - mouse
    
  • 3hbt, 2zwh, 1nwk, 1j6z, 3g37, 2y83 – rAa – rabbit
    
  • 4a7f, 4a7h, 4a7l – rAa + tropomyosin α-1 + myosin heavy chain (mutant) – Cryo EM
    
  • 2q1n, 2q31, 2a5x, 1rdw, 1rfq, 1lcu – rAa – dimer
    
  • 3mfp, 4a7n, 3j8i, 3j8j, 3j8k – rAa – Cryo EM
    
  • 2q36, 1qz5 – rAa+kabiramide C – dimer
    
  • 2hmp – rAa – protease cleaved
    
  • 2zwh, 2gwj, 2gwk – rAa-ATP
    
  • 2vyp – rAa+myxobacterial rhizopodin
    
  • 2v51, 2v52, 2yje, 2yjf – rAa+mMKL/Myocardin-like protein – mouse (m)
    
  • 2vcp – rAa+ neural wiskott-aldrich syndrome protein (hWASP) – human (h)
    
  • 2a3z, 2a40, 2a41 – rAa+cDNase I+domains of hWASP – cow (c)
    
  • 2ff3 - rAa+ hGelsolin +domains of hWASP
    
  • 2a42 – rAa+cDNase I
    
  • 4eah – rAa + formin-like protein 3 FH2 domain
    
  • 3daw – rAa+mTwinfilin-1
    
  • 3buz – rAa+Iota toxin component IA
    
  • 3b5u – rAa filament – fiber diffraction
    
  • 1eqy, 3cjb, 1p8z, 3ffk, 3tu5, 4pkg, 4pkh, 4pki – rAa+hGelsolin
    
  • 4b1u, 4b1v, 4b1w, 4b1x, 4b1y, 4b1z – rAa + phosphatase and actin regulator
    
  • 1rgi - rAa+hoGelsolin – horse (ho)
    
  • 1t44 - rAa+hGelsolin:mThymosin β-4
    
  • 4pl8 - rAa+ Thymosin β-4
    
  • 3u8x - rAa+DmThymosin β-4 - Drosophila melanogaster
    
  • 1esv - rAa+hGelsolin+ latrunculin A
    
  • 3cjc - rAa+hGelsolin+cDNase I
    
  • 2d1k - rAa+hWH2 domain of MIN+cDNase I
    
  • 2pbd – rAa+hProfilin-1
    
  • 2pav - rAa+hProfilin-1+hVASP
    
  • 2q97 – rAa+toxofilin – Toxoplasma gondii
    
  • 2q0r – rAa+pectenotoxin-2
    
  • 2q0u - rAa+pectenotoxin-2+latrunculin B
    
  • 1ijj - rAa+latrunculin A
    
  • 2fxu – rAa+bistramide A
    
  • 1wua – rAa+alpyronine A
    
  • 2asm, 2asp – rAa+reidispongiolide
    
  • 2aso – rAa+sphinxolide B
    
  • 1yxq – rAa+swinholide A
    
  • 1y64 – rAa+yBNI1 domain FH2 - yeast
    
  • 1sqk – rAa+DmCiboulot
    
  • 3sjh, 3u9d, 3u9z - rAa+DmCiboulot thymosin β-4 domain
    
  • 4k41, 1qz6, 1s22, 4k42, 4k43 - rAa+ macrolide
    
  • 3mn5 – rAa+ DmSpire WH2 domain
    
  • 2ff6 - rAa+DmCiboulot+hGelsolin
    
  • 1s22 – rAa+ulapualide A
    
  • 1qz6 – rAa+jaspisamide A
    
  • 1lot, 1kxp, 1ma9 – rAa+hVitamin D binding protein
    
  • 3m1f – rAa+VOPL WH2 domain
    
  • 3m3n – rAa+mN-WASP
    
  • 3m6g – rAa+lobophorolide
    
  • 3tpq – rAa + MAL RPEL domain
    
  • 3ue5 – rAa + spire domain D
    
  • 4gy2 – rAa + ι toxin component IA
    
  • 4h0t – rAa + ι toxin component IA + ADPR
    
  • 4h03, 4h0v, 4h0x, 4h0y – rAa + ι toxin component IA + NAD
    
  • 4jhd – DmAa + protein cordon-bleu WH2 domain
    
  • 4cbu – Aa + gelsolin – Plasmodium falciparum
    
  • 4cbw – PbAa + gelsolin – Plasmodium berghei
    
• β actin (Ab)
  • 3lue – hAb+hAlpha-actinin
    
  • 3byh – hAb+hFimbrin ABD2 – Cryo EM
    
  • 2oan – cAb
    
  • 3j0s – cAb + cofilin 2
    
  • 3u4l, 3ub5 – Ab + profilin-1 - bovine
    
  • 4cbx – PbAb + gelsolin
    
• γ 1 actin (Ag)
  • 1atn – rAg+cDNase I
    
  • 3chw – Major DdAg+hProfilin+poly-Pro repeat – Dictyostelium discoideum
    
  • 3ci5, 3cip, 1nmd - Major DdAg+hGelsolin
    
  • 3a5l, 3a5m, 3a5n, 3a5o - Major DdAg+hGelsolin (mutant)
    
  • 1c0g, 1dej – DdAg:tetrahymenatA+hGelsolin
    
  • 1nm1 - DdAg+hGelsolin+Mg-ATP
    
  • 1nlv, 1c0f – DdAg+hGelsolin
    
  • 1d4x – Ag 1/3+hGelsolin – C. elegans
    
  • 1h1v – hAg+rGelsolin
    
  • 1hlu, 2btf – cAg+cProfilin
    
  • 1o1g, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o18, 1o19, 1mvw, 1m8q –cAg+cMyosin II - tomography
    
  • 3eks – DmAg 5c (mutant)
    
  • 3eku – DmAg 5c (mutant)+cytochalasin D
    
  • 3el2, 2hf4 - DmAg 5c (mutant)+Ca-ATP
    
  • 2hf3 - DmAg 5c (mutant)+Ca-ADP
    
  • 3w3d – cAg + DNase I
    
  • 3b63 – actin filament – Limulus polyphemus
    
  • 1yvn – yA (mutant)+hGelsolin
    
  • 1yag - yA+hGelsolin
    
  • 3mmv – DmA-5C+spire WH2 domain
    
  • 3mn6, 3mn7, 3mn9 - DmA-5C (mutant)+spire
    
  • 4efh – A + spire domains C,D – Acanthamoeba castellanii