3v7o

Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)

Structural highlights 3v7o is a 2 chain structure with sequence from Eborr. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: Gene: VP30 (EBORR) Resources: FirstGlance, OCA, RCSB, PDBsum Function [VP30_EBORR] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity). Publication Abstract from PubMed The ebolaviruses can cause severe hemorrhagic fever. Essential to the ebolavirus life cycle is the protein VP30, which serves as a transcriptional cofactor. Here, the crystal structure of the C-terminal, NP-binding domain of VP30 from Reston ebolavirus is presented. Reston VP30 and Ebola VP30 both form homodimers, but the dimeric interfaces are rotated relative to each other, suggesting subtle inherent differences or flexibility in the dimeric interface. Structure of the Reston ebolavirus VP30 C-terminal domain.,Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi:, 10.1107/S2053230X14003811. Epub 2014 Mar 25. PMID:24699737 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nucleoprotein Transcriptional activator

spinqualitylabelsall models 3v7o, resolution 2.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image