Uridine 5'-monophosphate synthase

Uridine 5’-monophosphate synthase (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP). UMPS N-terminal domain is an orotate phosphoribosyl transferase (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is orotidine 5’-phosphate decarboxylase (OPD) which decarboxylates OMP to form UMP.

3D structures of uridine 5'-monophosphate synthase3D structures of uridine 5'-monophosphate synthase

Updated on 17-December-2014

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• Uridine 5’-monophosphate synthase OPD subunit
  • 3gdk - yOPD – yeast
    
  • 1dqw, 3gdr, 3gdm – yOPD (mutant)
    
  • 2eaw, 2jgy, 2p1f, 2qcc, 2qce - hOPD – human
• Uridine 5’-monophosphate synthase OPD subunit complex
  • 2v30, 2qcd - hOPD + UMP
    
  • 3ewy - hOPD (mutant) + UMP
    
  • 3gdl - yOPD + UMP derivative
    
  • 1dqx, 3gdt - yOPD (mutant) + UMP derivative
    
  • 2qcg, 2qch, 3bgg, 3bgj, 3bk0, 3g3d, 3g3m, 3ewz, 3ex2, 3ex3, 3ex4, 3dbp, 3l0k, 3l0n, 3mo7, 3mw7 - hOPD + UMP derivative
    
  • 3bvj - hOPD + xanthosine 5’-monophosphate
    
  • 2qcf, 2qcm, 2qcn, 3ewu, 3ewx, 3ex6 - hOPD (mutant) + UMP derivative
    
  • 3mi2, 4hib, 4hkp - hOPD + inhibitor
    
  • 3ex1 - hOPD + UMP derivative + UMP
    
  • 2qcl - yOPD (mutant) + OMP
• Uridine 5’-monophosphate synthase OPRT subunit complex
  • 2wns - hOPRT + OMP