Pseudouridine synthase

tRNA pseudouridine synthase (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine. PUS are active in the ribosomal large subunit (Rlu) and ribosomal small subunit (Rsu). Probable tRNA pseudouridine synthase (PPUS) is a similar enzyme.

3D Structures of tRNA pseudouridine synthase3D Structures of tRNA pseudouridine synthase

Updated on 15-December-2014

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• tRNA pseudouridine synthase
  • 1dj0 – EcPUS I – Escherichia coli
    
  • 1ksk, 1ksl – EcPUS RsuA
    
  • 1vio - PUS RsuA – Haemophilus influenzae
    
  • 1xpi - EcPUS RluC catalytic domain
    
  • 1v9k - EcPUS RluC C-terminal domain (mutant)
    
  • 2ist - EcPUS RluD
    
  • 1prz, 1qyu, 1v9f - EcPUS RluD catalytic domain
    
  • 2olw - EcPUS RluE
    
  • 2oml - EcPUS RluE catalytic domain
    
  • 2gml - EcPUS RluF catalytic domain
    
  • 4iqm, 4its, 4j37, 4nz6 - hPUS Pus1 catalytic domain - human
    
  • 4nz7 - hPUS Pus1 catalytic domain (mutant)
    
  • 1vs3 – PUS TruA – Thermus thermophilus
    
  • 1sgv – PUS TruB – Mycobacterium tuberculosis
    
  • 1si7, 1szw, 1sb7 - EcPUS TruD
• tRNA pseudouridine synthase complex with RNA
  • 1k8w – EcPUS B + stem-loop RNA
    
  • 1zl3 - EcPUS B (mutant) + stem-loop RNA
    
  • 2i82 – EcPUS RluA + RNA
    
  • 3dh3 - EcPUS RluF + RNA
    
  • 2nqp, 2nr0, 2nre – EcPUS TruA + Leu-tRNA
    
  • 3hjw, 3lwo, 3lwp, 3lwq, 3lwr, 3lwv – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA – Pyrococcus furiosus
    
  • 3mqk - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA
    
  • 3hjy - PfPUS Cbf5 + ribosome biogenesis protein NOP10 + RNA
    
  • 1ze2 - TmPUS B + RNA
    
  • 2ab4 - TmPUS B (mutant) + RNA
    
  • 1r3e, 1r3f - EcPUS B + RNA
    
• Probable tRNA pseudouridine synthase
  • 2apo – PPUS + ribosome biogenesis protein Nop10 – Methanocaldococcus jannaschii
    
  • 2ey4 - PfPPUS Cbf5 + ribosome biogenesis protein Nop10 + small nucleolar RNP
    
  • 2hvy, 3hax - PfPPUS B + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA
    
  • 2rfk - PfPUS B + ribosome biogenesis protein Nop10 + small nucleolar RNP + RNA
    
  • 3hay - PfPPUS B + ribosome biogenesis protein Nop10 + ribosomal protein L7 + small nucleolar RNP + RNA
    
  • 2aus – PPUS B + ribosome biogenesis protein Nop10 – Pyrococcus abyssi
    
  • 1z2z – PPUS D – Methanosarcina mazei