<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo)' scene=>
Integrins (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain.
3D structures of integrin3D structures of integrin
Updated on 27-November-2014
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- IG CR3
- 1ido – hIG I domain + Mg – human
- 1jlm - hIG I domain + Mn
- IG CD11a or IG α-L
- 1lfa - hIG I domain + Mn
- 1zon - hIG I domain
- 1zoo, 1zop, 3f74 - hIG I domain + Mg
- 1mq9 - hIG I domain (mutant) + Mn
- 1mjn - hIG I domain (mutant) + Mg
- 1mqa - hIG I domain (mutant)
- 2k8o – hIG cytoplasmic domain (mutant) – NMR
- IG CD11a complexes
- 1cqp - hIG I domain + lovastatin + Mg
- 1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
- 1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
- 1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
- 2o7n, 3m6f - hIG I domain + antagonist
- 1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
- 4ixd - hIG I domain + activator + Mg
- 3f78 - hIG I domain + anesthetic + Mg
- 3eoa, 3eob - hIG I domain + antibody
- 3hi6 - hIG I domain (mutant) + antibody + Mn
- IG CD11b
- 1bho - hIG I domain + Mg
- 1bhq - hIG I domain + Cd
- 1m1u - hIG I domain (mutant) + Ca
- 1n9z - hIG I domain (mutant) + Mg
- 1idn, 1na5 - hIG I domain
- 1mf7 - hIG I domain (mutant)
- IG CD11c
- 1n3y - hIG I domain (mutant)
- IG α-1 (CD49a)
- 1ck4 - rIG I domain – rat
- 4a0q - hIG I domain (mutant) + Mg
- 2l8s - hIG transmembrane domain – NMR
- 1mhp - rIG I domain (mutant) + antibody + Mn
- 2b2x - rIG I domain (mutant) + antibody + Mg
- 2m32 - hIG I domain + collagen peptide
- IG α-2 (CD49b)
- 1dzi, 4bj3 - hIG I domain + collagen peptide
- 1v7p - hIG I domain (mutant) + EMS16 + Mn
- IG α-2b
- 2k1a - hIG transmembrane domain – NMR
- IG α-1 β-1 (CD49a-CD49b)
- 1qc5, 1qcy - hIG I domain (mutant) + Mg
- 1pt6 - hIG I domain + Mg
- IG α-2 (CD49b) β
- 1aox - hIG I domain (mutant) + Mg
- 1s4w - hIG cytoplasmic domain]] - NMR
- IG α-2b β-3 (CD61)
- 1kup, 1kuz – hIG proximal domain – NMR
- 1m8o - hIG cytoplasmic domain – NMR
- 4cak – hIG – Cryo-EM
- 2k9j, 2knc - hIG transmembrane domain – NMR
- 1tye, 3fcu, 3fcs – hIG + Mg
- 3fc3 – hIG (mutant) + Mg
- 2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig, 3zdx, 3zdy, 3zdz, 3ze0, 3ze1, 3ze2 – hIG headpiece + antibody + Mg
- 2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
- 2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg
- IG α-4
- IG α-4 (CD49d) β-7
- 3v4p - hIG headpiece (mutant) + antibody + Mg
- 3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
- IG α-5 (CD49e) β-1 (CD29)
- 3vi3 - hIG headpiece + antibody + Mg
- 3vi4 - hIG headpiece + antibody + peptide + Mg
- IG α-5 (CD49e) β-3 (CD61)
- 3ije – hIG + Ca
- 1m1x - hIG extracellular domain + Mn
- 1u8c – hIG psi domain + Ca
- 1jv2 - hIG I domain + platelet membrane glycoprotein IIIA + Ca
- 1l5g - hIG I domain + tripeptide + Mn
- IG α-M
- IG α-X
- 2luv – hIG cytoplasmic domain – NMR
- IG α-X β-2 (CD18)
- IG α-V β-3
- IG β-1D
- 3g9w – hIG cytoplasmic tail + talin 2 F2-F3 domain
- IG β-2 (CD18)
- 2p26, 2p28 – hIG phe2 + phe3 domains
- 1yuk – hIG chain A PSI domain + chain B I-EGF domain
- IG β-3 (CD61)
- 1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
- 2rmz, 2rn0 – hIG transmembrane domain – NMR
- 2l91 - hIG transmembrane domain (mutant) – NMR
- 2l1c – hIG cytoplasmic tail + SHC
- IG β-4 (CD104)
- 2f7q, 3f7r, 1qg3, 3f7q - hIG fibronectin type III domain
- 2yrz – hIG fibronectin type III domain – NMR
- 3f7p - hIG fibronectin type III domain + plectin-1 + Ca
- 3fq4, 3fso, 3h6a – hIG Calx-β domain