Fibroblast growth factor

Fibroblast growth factors (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family. FGF signaling is important in the pathogenesis of a variety of tumor types.

• FGF1 is called acidic FGF.
  
• FGF2 is called basic FGF.
  
• FGF7 is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound.

3D structures of fibroblast growth factor3D structures of fibroblast growth factor

Updated on 25-November-2014

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• FGF1
  • 1fmm – FGF1 – Notophthalmus viridescens - NMR
    
  • 1afc – bFGF1 + HS – bovine
    
  • 1bar – bFGF1
    
  • 2j3p – rFGF1 - rat
    
  • 3hal – FGF1 - rabbit
    
  • 2afg, 1jqz, 1rg8 – hFGF1 - human
    
  • 1jt3, 1jt4, 1jt5, 1jt7, 1jtc, 1k5u, 1k5v, 1m16, 1jy0, 1nzk, 1p63, 1pzz, 1q03, 1q04, 1yto, 1z2v, 1z4s, 2aqz, 2hw9, 2hwa, 2hwm, 2hz9, 2ntd, 3b9u, 3ba4, 3ba5, 3ba7, 3bad, 3bag, 3bah, 3bao, 3baq, 3bau, 3bav, 3bb2, 2q9x, 3crg, 3crh, 3cri, 3cqa, 3fgm, 3fj8, 3fj9, 3fja, 3fjb, 3fjc, 3fjd, 3fje, 3fjf, 3fjh, 3fji, 3fjj, 3fjk, 3hom, 3o3q – hFGF1 (mutant)
    
  • 1dzd, 2rq9 – hFGF1 - NMR
    
  • 1dzc – hFGF1 (mutant) - NMR
    
• FGF1 complex with small molecule
  • 1axm, 2axm – hFGF1 + HS
    
  • 3ud7, 3ud8, 3ud9, 3uda – hFGF1 + disaccharide
    
  • 2uus – rFGF1 + HS
    
  • 2erm – hFGF1 + HS - NMR
    
  • 1rml – hFGF1 + naphthalene trisulphonate - NMR
    
  • 1hkn – hFGF1 + naphthalene trisulphonate
    
  • 2k8r – hFGF1 + anti-angiogenic drug - NMR
    
  • 3k1x – hFGF1 + vasoprotectant drug
    
  • 3jut – hFGF1 + inhibitor
    
  • 2ki4, 2ki6 – hFGF1 + S100-A13
    
• FGF1 complex with FGF receptor
  • 1e0o – hFGF1 (mutant) + hFGFR2 (mutant) + HS
    
  • 3oj2, 3ojm, 1djs – hFGF1 + hFGFR2 (mutant)
    
  • 1evt – hFGF1 + hFGFR1
    
  • 3ojv – hFGF1 + hFGFR1 (mutant)
    
  • 1ry7 – hFGF1 + hFGFR3
    
  • 3cu1 – hFGF1 + hFGFR2
    
• FGF2
  • 2fgf – hFGF2 precursor
    
  • 1fga, 4fgf, 1bas, 1bfg, 2bfh, 1bff – hFGF2
    
  • 1wvz, 2k43, 2k4a – hFGF2 - NMR
    
  • 1bla, 1bld – hFGF2 (mutant) - NMR
    
  • 1bfb, 1bfc – hFGF2 + heparin
    
  • 1cvs – hFGF2 (mutant) + hFGFR1 (mutant)
    
  • 1fq9 – hFGF2 (mutant) + hFGFR1 (mutant) + HS
    
  • 1ev2 - hFGF2 (mutant) + hFGFR2
    
  • 2m49 - hFGF2 (mutant) + S100-B
    
• FGF4
  • 1ijt – hFGF4 b-trefoil domain
    
• FGF7
  • 1qqk – rFGF7
    
  • 1qql – rFGF7/hFGF1
    
• FGF8
  • 2fdb – hFGF8b + hFGFR2
    
• FGF9
  • 1g82, 1ihk – hFGF9
    
• FGF10
  • 1nun – hFGF10 + hFGFR2
    
• FGF12
  • 1q1u – hFGF12 (mutant)
    
• FGF13
  • 3hbw – hFGF13
    
  • 4dck – hFGF13 + calmodulin + sodium channel subunit α
    
• FGF19
  • 1pwa, 2p23 – hFGF19
    
• FGF20
  • 3f1r – hFGF20
    
• FGF23
  • 2p39 – hFGF23