DNA methyltransferase

DNA methyltransferase (DNMT) catalyzes the transfer of methyl group to DNA. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. The SAM analog S-adenosyl homocysteine (SAH) is a powerful inhibitor of DNMT.

3D Structures of DNA methyltransferase3D Structures of DNA methyltransferase

Updated on 24-November-2014

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• Methylguanine DNMT
  • 1sfe – O6-methylguanine DNMT C terminal – Escherichia coli
  • 1qnt, 1eh6, 3llr - hO6-methylguanine DNMT – human
  • 1t38 - hO6-methylguanine DNMT (mutant) + DNA
  • 1t39, 1yfh - hO6-methylguanine DNMT + DNA
  • 1eh7 - hO6-methylguanine DNMT methylated
  • 1eh8 - hO6-methylguanine DNMT benzylated
    
  • 1mgt - O6-methylguanine DNMT – Thermococcus kodakarensis
    
  • 1wrj - O6-methylguanine DNMT - Sulfolobus tokodaii
  • 2g7h - O6-methylguanine DNMT – Methanocaldococcus jannaschii
  • 2kif, 2kim - O6-methylguanine DNMT – Vibrio parahaemolyticus - NMR
    
  • 4bhb, 4bhc - O6-methylguanine DNMT (mutant) – Mycobacterium tuberculosis
    
• Methylcytosine DNMT
  • 2qrv - h-cytosine DNMT
  • 3epz - h-cytosine DNMT replecation foci-targeting sequence
  • 3flg - h-cytosine DNMT ADD domain
  • 3a1a - h-cytosine DNMT PWWP domain
  • 1g55 - h-cytosine DNMT2 (mutant)
    
  • 3qkj - h-cytosine DNMT 3β
    
  • 3av4, 1khc - m-cytosine DNMT – mouse
  • 2uyc, 2uyh, 2uz4 - Hh-cytosine DNMT (mutant) + DNA + SAH
  • 3a1b - h-cytosine DNMT ADD domain + histone H3
  • 3pt6, 3pt9, 4da4 – m-cytosine DNMT + DNA

• • 3av5 - m-cytosine DNMT + SAH
  • 3av6 - m-cytosine DNMT + SAM
  • 3swr - h-cytosine DNMT + sinefungin
  • 1boo - cytosine DNMT (mutant) – Proteus vulgaris
    
  • 3qv2 - cytosine DNMT + SAH – Entamoeba histolytica
    
  • 2uyc, 2uyh, 2uz4, 1fjx – Hh-cytosine DNMT (mutant) + DNA + SAH - Haemophilus haemolyticus
    
  • 2c7o, 2c7p, 2c7q, 2c7r, 3pta – Hh-cytosine DNMT + DNA + S-adenonosyl cysteine
    
  • 1hmy – Hh-cytosine Haeiii DNMT + SAM
  • 1m0e - Hh-cytosine DNMT (mutant) + DNA + inhibitor
  • 2i9k - Hh-cytosine DNMT (mutant) + DNA
  • 2hr1 - Hh-cytosine DNMT + DNA + ADOHCY
  • 2z6q, 2z6u, 2zcj - Hh-cytosine DNMT (mutant) + DNA + ADOHCY
  • 1svu - Hh-cytosine DNMT (mutant)
    
  • 4fsx – c-cytosine DNMT + SAH – corn
    
  • 4ft2, 4ft4 – c-cytosine DNMT + histone H3 peptide
    
  • 4h0n - cytosine DNMT (mutant) – Spodoptera frugiperda
• Methyladenine DNMT
  • 1nw5 – RsN6-adenine DNMT + SAM – Rhodobacter sphaeroides
  • 1nw6 - RsN6-adenine DNMT + sinefungin
    
  • 1nw7 - RsN6-adenine DNMT + SAH
    
  • 1nw8 - RsN6-adenine DNMT (mutant)
  • 2ibs, 2ibt, 2ih2, 2ih4, 2ih5, 2np6, 2np7, 1g38 - Ta-adenine DNMT Taqi + DNA + cofactor analog – Thermus aquaticus
    
  • 1aqi – Ta-adenine DNMT Taqi + SAH
    
  • 1aqj – Ta-adenine DNMT Taqi + sinefugin
    
  • 2adm - Ta-adenine DNMT Taqi + SAM
    
  • 1g60 - adenine DNMT + SAM – Moraxella bovis