Clp Protease

spinqualitylabelsall models PDB ID 1tyf Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
E. coli Clp protease, 1tyf
Activity:	Endopeptidase Clp, with EC number 3.4.21.92
Structural annotation: Resources: CATH : 1Tyfa00, 1Tyfb00, 1Tyfc00, 1Tyfd00, 1Tyfe00, 1Tyff00, 1Tyfg00, 1Tyfh00, 1Tyfi00, 1Tyfj00, 1Tyfk00, 1Tyfl00, 1Tyfm00, 1Tyfn00 InterPro : Ipr001907 Pfam : PF00574 SCOP : d1tyfa_, d1tyfb_, d1tyfc_, d1tyfd_, d1tyfe_, d1tyff_, d1tyfg_, d1tyfh_, d1tyfi_, d1tyfj_, d1tyfk_, d1tyfl_, d1tyfm_, d1tyfn_ UniProt : P0A6G7
Functional annotation: Cellular component: cytoplasm membrane fraction Biological process: response to stress proteolysis Molecular function: endopeptidase Clp activity serine-type endopeptidase activity peptidase activity hydrolase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Clp protease (CLP) is a serine peptidase which hydrolyzes proteins in the presence of ATP and Mg+2 ion. CLP is found in mitochondria. CLP participates in degradation of misfolded proteins. CLP is a heterodimer containing an ATP-binding regulatory subunit A and catalytic subunit P. For more details see Clp protease.

3D structures of Clp protease3D structures of Clp protease

Updated on 20-November-2014

{"openlevels":0}

• CLP P subunit
  • 1tyf, 1yg6 – EcCLP – Escherichia coli
    
  • 1yg8, 3hln - EcCLP (mutant)
    
  • 1y7o – CLP – Streptococcus pneumoniae
    
  • 1tg6 - CLP – human
    
  • 2f6i, 4gm2, 4hnk - CLP – Plasmodium falciparum
    
  • 2cby, 2ce3, 2c8t - CLP – Mycobacterium tuberculosis
    
  • 3fes - CLP – Clostridium difficile
    
  • 3ktg, 3kth, 3tt6 – BsCLP – Bacillus subtilis
    
  • 3p2l - CLP – Francisella tulerensis
    
  • 3q7h - CLP – Coxiella burnetii
    
  • 3qwd, 3st9, 3sta, 3v5e, 4emm, 4mxi - SaCLP – Staphylococcus aureus
    
  • 3v5i, 4emp - SaCLP (mutant)
    
  • 2zl0 - HpCLP – Helicobacter pylori
    
  • 2zl3 - HpCLP (mutant)
    
  • 4jcq, 4jct – LmCLP – Listeria monocytogenes
    
  • 4jcr - LmCLP (mutant)
    
• CLP P subunit binary complex
  • 2fzs, 3mt6 - EcCLP + peptide
    
  • 2zl2 - HpCLP + peptide
    
  • 2zl4 - HpCLP (mutant) + peptide
    
  • 3kti, 3ktj, 3ktk - BsCLP + peptide
    
  • 3tt7 - BsCLP + DFP
• CLP A subunit
  • 1k6k, 1r6c – EcCLP N terminal
    
  • 1ovx - EcCLP N terminal - NMR
    
  • 1ksf, 1r6b – EcCLP (mutant)
    
  • 1um8 – HpCLP
• CLP A subunit binary complex
  • 1lzw, 1mg9, 1mbu, 1mbv, 1mbx – EcCLP + CLP adaptor protein ClpS
    
  • 1r6o, 1r6q - EcCLP N terminal + CLP adaptor protein ClpS