Centromere protein

<StructureSection load='3vh5' size='340' side='right' caption='Structure of chicken CENP-X (yellow), CENP-S (grey), CENP-W (purple) and CENP-T C-terminal (dark green) (PDB code 3vh5).' scene=>

FunctionFunction

Centromere proteins (CENP) X,S,W,T make up the kinetochore structure on chromatids where the spindle fibers attach during cell division to pull the chromatids apart.
• CENP-X is a component of the Fanconi Anemia core.
• CENP-B facilitates centromere formation.
• CENP-A is a component of modified nucleosome replacing hitone H3.
• CENP-E is a motor protein involved inchromosome movement.
• CENP-M is involved in the kinetochore assembly.

• Inner centromere protein (INCENP) is a component of the chromosomal passenger complex which regulates mitosis. INCENP are localized at the centromeres during mid-metaphase of the cell cycle.

3D structures of centromere protein3D structures of centromere protein

Updated on 20-November-2014

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• Centromere proteins X, S, W, T
  • 3b0b – cCENP-X + CENP-S – chicken
    
  • 4dra, 4e44, 4ne3, 4ne5, 4ne6 – hCENP-X + CENP-S – human
    
  • 3vh5, 3vh6 – cCENP-X + CENP-S (mutant) + CENP-W + CENP-T C-terminal (mutant)
    
  • 4drb, 4e45 – hCENP-X + CENP-S + Fanconi anemia group M protein
    
  • 4ndy, 4ne1 – hCENP-X + CENP-S + DNA
    
  • 3b0c, 3b0d – cCENP-T + CENP-W
    
  • 3vza – cCENP-T residues 63-98 (mutant) + Spc24 + Spc25
    
• Inner centromere protein
  • 2bfx, 4b8l – fINCENP residues 798-840 + aurora kinase – frog
    
  • 2bfy – fINCENP residues 798-840 + aurora kinase + hesperadin
    
  • 2vgp, 2vrx, 3ztx, 4b8m – fINCENP residues 798-840 + aurora kinase + inhibitor
    
  • 4af3 – hINCENP residues 835-903 + aurora kinase + inhibitor
    
  • 2vgo – fINCENP residues 798-840 + aurora kinase + reversine
    
  • 4c2v – fINCENP residues 798-840 + aurora kinase + barasertib
    
  • 4c2w – fINCENP residues 798-840 + aurora kinase + AMPPNP
    
  • 2qfa – hINCENP residues 1-47 + surviving + borealin
    
• Centromere protein A
  • 3nqu – hCENP-A + histone H4
    
  • 3nqj – hCENP-A residues 60-140 + histone H4
    
  • 3r45 – hCENP-A + histone H4 + Holliday junction recognition protein
    
  • 3an2 – hCENP-A + histone H4 + histone H2A + histone H2B + DNA
    
• Centromere protein B
  • 1bw6 – hCENP-B DNA-binding domain - NMR
    
  • 1ufi – hCENP-B dimerization domain
    
  • 1hlv – hCENP-B DNA-binding domain + DNA
    
• Centromere protein E
  • 1t5c – hCENP-E motor domain
    
• Centromere protein M
  • 4p0t – hCENP-M