Jumonji domain-containing protein

<StructureSection load='2p5b' size='340' side='right' caption='Structure of human Jumonji domain-containing protein 2A catalytic domain complex with oxalylglycine, Fe+2 ion, Zn+2 ion (grey) and histone H3 peptide with trimethyllysine (aqua and wheat) (PDB code 2p5b).' scene=>

FunctionFunction

Jumonji domain-containing protein 2A (Jmjd2a) catalyzes the demethylation of trimethylated histone at lysine residues 9 and 36 producing the dimethylated form. Jmjd2a domains contain: N-terminal, catalytic core (residues 1-350), 2 TUDOR domains (residues 895-1011) , 2 PHD-type zinc fingers and C-terminal domain. Jmjd2a is Fe+2 and α-ketoglutarate dependent. Methylation of histones in the chromatin is involved in regulation of gene activity, chromatin structure and epigenetic memory.

3D structures of jumonji domain-containing protein 2A3D structures of jumonji domain-containing protein 2A

Updated on 01-September-2014

Jmjd2aJmjd2a

2gf7, 2qqr – hJmjd2a double TUDOR domain – human
2gp3 – hJmjd2a catalytic domain + Fe

Jmjd2a binary complex with peptideJmjd2a binary complex with peptide

2gfa – hJmjd2a double TUDOR domain + peptide with trimethyllysine
2qqs – hJmjd2a double TUDOR domain + histone H4 peptide with trimethyllysine
2oq6, 2os2 – hJmjd2a catalytic domain + Ni + histone H3 peptide with trimethyllysine
2ot7 – hJmjd2a catalytic domain + Ni + histone H3 peptide with methyllysine
2pxj – hJmjd2a catalytic domain + Fe + histone H3 peptide with methyllysine
2ox0 – hJmjd2a catalytic domain + Ni + histone H3 peptide with dimethyllysine

Jmjd2a binary complex with other moleculesJmjd2a binary complex with other molecules

2oq7 – hJmjd2a catalytic domain + Ni + oxalylglycine
2vd7, 2wwj, 3njy, 3pdq, 3rvh, 4gd4, 4ai9, 4bis – hJmjd2a catalytic domain + Ni + inhibitor
2gp5 – hJmjd2a catalytic domain + Fe + α-ketoglutarate
2ybk – hJmjd2a catalytic domain + Ni + α-ketoglutarate derivative

Jmjd2a ternary complexJmjd2a ternary complex

2q8c, 2ybp, 2ybs – hJmjd2a catalytic domain + Fe + histone H3 peptide with trimethyllysine + α-ketoglutarate derivative
2q8d – hJmjd2a catalytic domain + Fe + histone H3 peptide with trimethyllysine + succinate
2q8c, 2p5b – hJmjd2a catalytic domain + Fe + histone H3 peptide with trimethyllysine + oxalylglycine
2q8c – hJmjd2a catalytic domain + Ni + histone H3 peptide with trimethyllysine + oxalylcysteine