Trichodiene synthase

Template:STRUCTURE 2q9z

Trichodiene synthase (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP). TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a Sesquiterpene. TCS contains metalion-binding motifs.

3D Structures of trichodiene synthase3D Structures of trichodiene synthase

Updated on 21-August-2014

1jfa – FsTCS – Fusarium sporotrichioides
1kiy, 1yj4, 2ps6 – FsTCS (mutant)
2aek, 2ps4, 2ps7 – FsTCS (mutant) + Mg
1jfg, 2q9z – FsTCS + PP + Mg
1kiz, 1yyq, 2ps5, 2ps8 – FsTCS (mutant) + PP + Mg
1yyr, 1yys, 1yyt, 1yyu, 2ael, 2aet – FsTCS (mutant) + PP + Mg + azabisabolene
2q9y – FsTCS + PP + Mg + benzyl triethyl ammonium

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Michal Harel, Alexander Berchansky, Joel L. Sussman