SAGA-associated factor

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<StructureSection load='3mhs' size='350' side='right' caption='Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow) and UB8P (grey) (PDB entry 3mhs)' scene=>

SAGA-associated factor (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes.

  • SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation.
  • SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.

3D structures of SAGA-associated factor3D structures of SAGA-associated factor

Updated on 20-August-2014

SGF11SGF11

2lo2 – ySGF zinc finger domain – yeast – NMR
3kik, 3kjl – ySGF Sus1-binding domain + Sus1
3mhh, 3m99, 4fip, 4fjc, 4fk5 – yUBP8 + Sus1 +SGF73 - yeast
3mhs – yUBP8 + Sus1 +SGF73 + ubiquitin

SGF29SGF29

3me9, 3mea, 3met, 3meu, 3mev, 3mew, 3mp1, 3mp6 – hSGF tudor domain + histone H3 peptide – human
3lx7, 3mp8 - hSGF tudor domain

SGF73SGF73

2lo3 – ySGF zinc finger domain – NMR

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman
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