Lactoperoxidase

Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. The short-lived oxidized intermediates of the reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion.

3D structures of lactoperoxidase3D structures of lactoperoxidase

Updated on 19-August-2014

Lactoperoxidase binary complexLactoperoxidase binary complex

2pt3 - bPLO + phosphate - bovine
2nqx – bPLO + I
2r5l – gLPO + I – goat
3nak – gLPO + formate
4ig5 – gLPO + methimazole

Lactoperoxidase ternary complexLactoperoxidase ternary complex

2gj1 – bLPO + carbonate + nitrate
2ips, 3eri, 3gc1 – bLPO + SCN + I
2qrb – bLPO + SCN + Cl
3bxi – bLPO + SCN + nitrate
4pnx - bPLO + bromomethane + I
2pum – bPLO + catechol + I
2gj1 – bLPO + carbonate + nitrate
3krq – bLPO + amino-triazole + I
2z5z – wbPLO + F + I – water buffalo
2o86 – wbPLO + nitrate + I
3erh - wbLPO + SCN + I
2ojv – gPLO + CN + I
3n8f - gLPO + SCN + nitrate
3niu – gLPO + diethylene glycol + phosphate
3rke - gPLO + inhibitor + I
2ikc – sLPO + carbonate + formate – sheep

Lactoperoxidase quaternary complexLactoperoxidase quaternary complex

3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
3gck - bPLO + benzylhydroxamic acid + SCN + I
3uba, 4gm7 - bPLO + hydroxycinnamic acid + SCN + I
3gcl, 2qqt - bPLO + aspirin + SCN + I
3i6n - bPLO + isoniazid + SCN + I
4ksz - bPLO + cystein + SCN + I
3nyh - bPLO + Br + Cl + SCN + I
3ogw - bPLO + indomethacin + SCN + I
3py4, 4gn6 - bPLO + paracetamol + SCN + I
3q9k - bPLO + phenyliso-SCN + SCN + I
3ql6 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
3s4f, 4njb, 4nt3 - bPLO + pyridine derivative + SCN + I
3r4x, 3tuw - bPLO + pyrazine derivative + SCN + I
3r5o - bPLO + methoxyphenol + SCN + I
3tgy - bPLO + ascorbate + SCN + I
3v6q - bPLO + CO + SCN + I
2gjm - wbPLO + carbonate + SCN + I
3faq – wbLPO + CN + SCN + I
3fnl - wbPLO + salicylhydroxamic acid + SCN + I
2e9e – gPLO + nitrate + carbonate + SCN + CN
2efb – gPLO + phosphate + carbonate + SCN + CN
3qf1 - gPLO + piperazine + SCN + I
4ljj - gPLO + acrylonitrile + SCN + I
4msf, 4oek - gPLO + phenol derivative+ SCN + I
2eha – gPLO + formate + carbonate + SCN
3r55, 4n7a - gPLO + pyrazine derivative + SCN + I
3sxv - gPLO + amitrole + SCN + I
3r5q - sPLO +tetrahydrofuran + SCN + I