2efb

From Proteopedia
Jump to navigation Jump to search

Crystal structure of the complex of goat lactoperoxidase with phosphate at 2.94 A resolutionCrystal structure of the complex of goat lactoperoxidase with phosphate at 2.94 A resolution

Structural highlights

2efb is a 2 chain structure with sequence from Capra hircus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.94Å
Ligands:, , , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PERL_CAPHI Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Benoy MJ, Essy AK, Sreekumar B, Haridas M. Thiocyanate mediated antifungal and antibacterial property of goat milk lactoperoxidase. Life Sci. 2000;66(25):2433-9. doi: 10.1016/s0024-3205(00)80003-x. PMID:10894086 doi:http://dx.doi.org/10.1016/s0024-3205(00)80003-x

2efb, resolution 2.94Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA