Glyoxalase

Glyoxalase (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism. GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione. GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II.

3D structures of glyoxalase3D structures of glyoxalase

Updated on 18-August-2014

Glyoxalase 1Glyoxalase 1

1bh5 – hGLO (mutant) – human
1fa8 – EcGLO – Escherichia coli
2c21 – GLO – Leishmania major
1fro – hGLO + benzyl glutathione
1qin, 1qip - hGLO + glutathione derivative
1f9z, 1fa5, 1fa6, 1fa7 – EcGLO + metal
2za0 – GLO + methyl gerfelin – mouse
3hdp – GLO + Ni – Clostridium acetobutylicum

Glyoxalase 2Glyoxalase 2

1xm8 – GLO – Arabidopsis thaliana
2p18 - LiGLO – Leishmania infantum
1qh3 – hGLO + actate + cacodylate
1qh5 – hGLO + glutathione derivative
2p1e – LiGLO + lactate

Glyoxalase 3Glyoxalase 3

4lru – GLO – Candida albicans